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In vivo Models for Drug Discovery
This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, incl...
The Promise of Low Dose Naltrexone Therapy
Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 for opiate and drug abuse treatment. When used at much lower doses in an off-label protocol referred to as low dose naltrexone (LDN), the drug has been shown to halt disease progression in Crohn's disease and certain cancers, to reduce symptoms in multiple sclerosis and autism, and to improve numerous autoimmune and neurodegenerative conditions, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). Grounded in clinical and scientific research, this book describes the history of naltrexone, its potential therapeutic uses, its effects on the immune system, its pharmacological properties, and how the drug is administered. It also lists fillers and compounding pharmacies, doctors who prescribe LDN, and patient resources, and includes interviews with LDN patients and researchers.
What Does it Mean to be Human? Life, Death, Personhood and the Transhumanist Movement
This book is a critical examination of the philosophical and moral issues in relation to human enhancement and the various related medical developments that are now rapidly moving from the laboratory into the clinical realm. In the book, the author critically examines technologies such as genetic engineering, neural implants, pharmacologic enhancement, and cryonic suspension from transhumanist and bioconservative positions, focusing primarily on moral issues and what it means to be a human in a setting where technological interventions sometimes impact strongly on our humanity. The author also introduces the notion that death is a process rather than an event, as well as identifies philosoph...
The Basal Ganglia VI
This volume represents the proceedings of the Sixth TriennialMeeting of the International Basal Ganglia Society, held in Brewster, Massachusetts from October 15-18, 1998. This volume focuses on thefunctions of the basal ganglia in health and disease and the neuralmechanisms that underpin these functions. This book is useful foranyone in the field of neuroscience, neuropharmacology, neurobiology, neuroanatomy and neurophysiology.
The Neuroscience of Depression
The Neuroscience of Depression: Features, Diagnosis and Treatment, is a comprehensive reference to the diagnosis and treatment of depression. This book provides readers with the mechanisms of depression reflecting on the interplay between depression and the biological and psychosocial processes. A detailed introduction to various episodes of depression, from PTSD to post-partum depression is provided, followed by a thorough discussion on biomarkers in depression and how to diagnose depression including the Hamilton Depression Rating scale. This book also includes three full sections on treatment options for depression, including pharmacological, behavioral and other novel regimes. The Neuroscience of Depression: Features, Diagnosis and Treatment is the only resource for researchers and practitioners studying, diagnosis and treating of depression. - Covers a pharmacological and behavioral treatment options - Features sections on diagnosis and biomarkers of depression - Discusses depression in children, teens and adults - Contains information on comorbidity of physical and mental conditions - Includes more than 250 illustrations and tables
The Development of Sex Differences and Similarities in Behavior
M. HAUG Universite Louis Pasteur, Laboratoire de Psychophysi%gie, URA 1295, 7, rue de /'Universite, 67000 Strasbourg, France This varied and impressive volume is a record of the major presentations at the NATO sponsored Advanced Research Workshop on The Development of Sex Differences and Similarities in Behaviour held at the Chateau de Bonas, Gers, France July 14-18, 1992. It is fitting that a meeting evaluating masculine and feminine 'characteristics' was located in the Gascony region immortalised in Alexandre Dumas epic, macho tale of The Three Musketeers. It is even more satisfying that Marc HAUG the French Director (a D' Artagnan equivalent) was ably assisted by a US/French Consortium of three co-Directors (Drs. Richard E. WHALEN, Claude ARON and Kathie L. OLSEN). The ARW also provided opportunities to explore the region around the Chateau, to appreciate the complex history of the area and to sample armagnac and other local gastronomic creations. A lively and varied cultural programme (classics to jazz) was also provided to maintain the interests and enthusiasms of the participants.
Models of Seizures and Epilepsy
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. - Provides a comprehensive reference detailing animal models of epilepsy and seizure - Offers insights on the use of novel technologies that can be applied in experimental epilepsy research - Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques - Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Progress in Psychobiology and Physiological Psychology
Progress in Psychobiology and Physiological Psychology: Volume 13 provides continuing information and a cumulative archive in physiological psychology through papers contributed by experts from related fields. The text covers topics such as the weaning from milk of infants; the effect of tachykinins on the regulation of body fluids; the brain mechanisms of aggression by electrical and chemical stimulation; and the behavioral and cardiovascular components of the defense reaction. Also covered are topics such as the behavioral neurobiology of circadian pacemakers, as well as the mechanisms of brain-stimulation reward. The book is recommended for medical doctors and psychologists who would like to know more about studies in the field of psychobiology and physiological psychology.
Photobiological Techniques
The fIrst edition of the Science 0/ Photobiology edited by Kendric C. Smith (plenum Press, 1977) was a comprehensive textbook of photobiology, devoting a chapter to each of the subdisciplines of the fIeld. At the end of many of these chapters there were brief descriptions of simple experiments that students could perform to demonstrate the principles discussed. In the succeeding years some photobiologists felt that a more complete publica tion of experiments in photobiology would be a useful teaching tool. Thus, in the 1980s the American Society for Photobiology (ASP) attempted to produce a laboratory manual in photobiology. Cognizant of these efforts, Kendric Smith elected to publish the se...
Bad Boys, Bad Men
'Bad Boys, Bad Men' examines the causes, manifestations and solutions to antisocial personality disorder in men. It summarises recent advances in genetics, brain imaging and psychophysiologic research that shed light on ASP.
