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Molecular Oncology Principles and Recent Advances
"Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecu"
Plant MicroRNAs
This second volume is a collection of new and updated protocols to study miRNA functions in plants. Chapters guide readers from the identification and detection of plant miRNAs, bioinformatic analyses, to strategies for functional analysis of miRNAs and their targets. Furthermore, it contains a few introductory chapters on plant miRNA functioning and, on their conservation, and evolution. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Plant MicroRNAs: Methods and Protocols, Second Edition aims to provide protocols to help new researchers while also supporting established researchers to broaden the scope of their investigations.
Current Topics on Renal Dysfunction: From Basics to Clinic
With renal dysfunction affecting millions worldwide, this book presents a timely and integrative look at emerging insights—from molecular foundations to clinical management. It explores the intricate mechanisms, systemic impact, and clinical complexities of kidney diseases in a multidisciplinary context. Spanning a broad spectrum of conditions, the book addresses renal tubular acidosis, polycystic kidney disease, renal lithiasis, diabetic kidney disease, and sodium imbalance–linked hypertension. Chapters delve into nephrotoxicity, loss of cellular identity in renal carcinoma, epigenetics, dysbiosis, and the evolving role of SGLT2 inhibitors. The book also highlights innovative approaches such as stem cell therapy and the systemic immune interactions that underlie chronic kidney injury. Key Features: Examines genetic and epigenetic underpinnings of renal disease Explores microbiota and immune system crosstalk in kidney pathology Discusses both acute and chronic conditions with clinical relevance Integrates foundational science with translational perspectives Includes emerging therapies and precision medicine approaches.
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