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Mechanisms and Emerging Therapies in Tremor Disorders
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
Dystonia
Dystonia: Etiology, Clinical Features, and Treatment is a comprehensive and up-to-date resource on all forms of generalized and focal dystonias. Its 19 chapters cover classification, genetics and genetic counseling, and electrophysiology, and provide detailed descriptions of the clinical features and treatment of these disorders. Therapeutic choices, which include botulinum toxin injections, intrathecal medications, oral pharmacotherapy, and surgery, are covered in detail. Chapters have been authored by internationally recognized experts in these disorders, and have been written with the practicing clinician in mind. This book is produced by WE MOVE (www.mdvu.org).
Clinical Applications of Botulinum Neurotoxin
Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.
Neuropsychiatric Symptoms of Movement Disorders
This is an up-to-date, comprehensive review of the neuropsychiatry of patients with movement disorders, i.e. Parkinson’s disease, Huntington’s disease, dystonia and others, by active authorities in the field, with an emphasis on diagnostic and management issues. This book includes critical appraisal of the methodological aspects and limitations of the current research on the neuropsychiatry of movement disorders and on unanswered questions/controversies. Symptomatology and pharmacological aspects of management are discussed, to provide robust information on drug dosages, side effects and interaction, in order to enable the reader to manage these patients more safely. Illustrative cases provide real life scenarios that are clinically relevant and engaging to read. Neuropsychiatric Symptoms of Movement Disorders is aimed at neurologists, movement disorder specialists and psychiatrists and will also be of interest to intensive care doctors, psychologists and neuropsychologists, research and specialist nurses, clinical researchers and methodologists.
Proceedings of the Medtronic Forum for Neuroscience and Neuro-Technology 2005
Leiden Univ., The Netherlands. First volume in new series offers research on the application of interventional neuroscience to the treatment of chronic pain and neurological disorders.
Movement Disorders Curricula
This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders.
Treatment of Dystonia
Comprehensive reference for neurologists, neurosurgeons and physical therapists on the treatment of all dystonias in children and adults.
Imaging Acute Neurologic Disease
While conventional magnetic resonance, X-ray-based, ultrasound, and nuclear medicine techniques are widely used to facilitate diagnosis, inform therapeutic decision-making, provide information regarding prognosis, and monitor therapeutic response in neurologic diseases, their practical value in acute clinical care is not as yet well-defined and the potential future development is not fully appreciated. This book provides a comprehensive survey of best practice for specialists and trainees in neurology, emergency medicine, neuroradiology, radiology, neurosurgery, and critical care. The symptom-based approach guides the choice of the available imaging tools for efficient, accurate, and cost-effective diagnosis to support immediate management of common and complex neurological disorders in the acute setting. Effective examination algorithms are included that integrate neurological and imaging concepts with the practical demands and constraints of emergency care. Written by leading international authorities, the book is extensively illustrated and contains many helpful case-histories.
