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Maturation Phenomenon in Cerebral Ischemia III
The maturation phenomenon refers to postischemic changes that develop hours or days following an ischemic insult. The delayed neuronal death of CA1 pyramidical cells of the hippocampus is a classic example. The report of the phenomenon has boosted research in this field, as it became evident that ischemic damage is not a sudden event but a process potentially susceptible to therapeutic intervention. In September 1990, the first international symposium on "Maturation Phenomenon in Cerebral Ischemia" was held in Tokyo. The second symposium was organized in Tokyo in March/April 1996. Since then, new developments have rapidly delivered information about the molecular nature and dynamics of mechanisms concerning cell death and recovery. This book contains the presentations of the 3rd international symposium held in Pozilly/Italy in April 1998. It outlines the present status of the investigation and provides further stimulation for research in this field.
Academic Freedom
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Brain Edema XV
More than 60 papers written by internationally recognized experts cover the broad spectrum of brain edema. The main topics treated are: ischemia & hemorrhage, trauma (experimental and clinical), cerebral hemorrhage, tumor, hydrocephlaus & intracranial pressure (ICP), neuromonitoring & neuroimaging, treatments, blood brain barrier, and miscellaneous.
Transplantation Pillars
Since the first successful kidney transplant in 1954 in Boston, MA, organ transplantation has become one of the most spectacular and consequential fields in 21st century medicine. In another historical milestone, in 2022, the U.S. reached 1 million transplants, with a record number for kidney (25,498), liver (9,528), heart (4,111), and lung (2,692) transplant procedures. A total of 14,903 people became deceased organ donors nationwide, and 6,466 individuals became living organ donors in 2022. The success of saving lives by donating an organ warrants recognition of pioneers in the field, which celebrates 70th anniversary. Frontiers in Transplantation provides such a venue to look back and adm...
Pathophysiology of the Blood-brain Barrier
The blood-brain barrier, a concept including all morphological and functional mechanisms that restricts or facilitates the passage of substances from blood to brain, enables the brain environment to be regulated relatively independently from concentration and fluctuations in plasma constituents. The various aspects on the blood-brain barrier have been extensively discussed in a number of recent symposia and our knowledge on the blood-brain barrier physiology has advanced impressively during the last decade. However, as to the pathophysiology and the long-term consequences of a transient or permanent barrier damage, little is known - a fact attributable to the limited amount of interest shown in this area of research until recently. The idea to arrange a Fernstrom symposium on the consequences of barrier damage emerged in 1987, when findings in Barbro Johansson's Laboratory of Experimental Neurology indicated that opening of the blood-brain barrier in various experimental models could lead to permanent neuronal injury."
