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Behavioral Neurobiology of Anxiety and Its Treatment
The book is part of a series on Current Topics in Behavioral Neurosciences, which has as its focus anxiety and its treatment. We have brought together a distinguished cadre of authors with the aim of covering a broad array of topics related to anxiety disorders, ranging from clinical diagnosis, epidemiology, preclinical neuroscience, and animal models to established and innovative therapeutic approaches. The book aims at bridging these disciplines to provide an update of literature relevant to understanding anxiety, its consequences, and its management. Following is a brief overview of the chapters and their content, meant to serve as a guide to navigating the book. The ?rst section covers c...
Drug Development in Psychiatry
The book reviews clinical trial methodology as it pertains to drug development in psychiatry. The reader will understand the process of drug development in psychiatry from discovery through marketing with the help of clinically relevant examples. The reader will appreciate the history of drug development in psychiatry dating back to the era of serendipitous discovery and culminating in an era of new and highly focused targets. Readers will understand how drug development in psychiatry has changed and adapted with the discovery of novel mechanism of action drugs. Novel drugs and disease targets have changed the way developers and regulatory agencies think about clinical trial methodology. The...
Novel Antischizophrenia Treatments
This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
Basic and Clinical Science of Mental and Addictive Disorders
This is the most comprehensive update of basic and clinical information available on mental, addictive and various neurological disorders. Virtually every basic and clinical scientific methodology that is relevant to our understanding and management of brain-related diseases is included in this volume. Readers will find up-to-the-minute studies in functional brain imaging, including MRI and EEG/ERP mapping, the latest application of molecular biology and genetics to solve clinical problems, as well as recent findings on schizophrenia, Alzheimer's disease, drug addiction and alcoholism, suicide and mood disorders. A unique feature of this publication are the nine chapters which examine chroni...
Trends in CNS Drug Discovery
Provides insights into the drug discovery innovations that are shaping future CNS therapies In the vast field of neuroscience, drug discovery targeting the central nervous system (CNS) presents both extraordinary opportunities and complex challenges. Disorders such as Alzheimer’s disease, schizophrenia, and epilepsy affect millions worldwide, demanding innovative therapeutic strategies. Yet understanding brain processes and overcoming the blood-brain barrier continue to pose significant hurdles for researchers and developers alike. Trends in CNS Drug Discovery offers a comprehensive overview of the methodologies, successes, and challenges shaping this critical area of pharmaceutical resear...
New Times
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Agmatine and Imidazolines
Major developments concerning imidazoline receptor (IR) molecular biology, cell signalling and purification of endogenous ligands have greatly expanded our understanding of the molecular nature of these proteins and of agmatine-metabolizing enzymes. The diversity of IR subtypes and the possible relationship of these receptors to the function of various organs and potential therapeutic targets in psychiatry and diabetes present new areas for discussion. The diversity of IR subtypes as well as a wide tissue distribution for imidazoline-selective binding sites has led to an appreciation that other organ systems besides the brain are also probably influenced by IR. (agmatine and harmane) have po...
Mathematical Reviews
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