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Current Perspectives on Substance Use Disorders in South Asia
This book is about public mental health needs and aspects of substance use disorders in South Asian countries. South Asia consists of eight countries with low- and middle-income backgrounds. The people of this region, with a combined population of around 2 billion, share common cultures, beliefs, and behavioral patterns regarding physical and mental health. Among them, more than 66 million people use different forms of substances including cannabis, opium and opiates, amphetamine, and prescription drugs. Substance abuse brings deadly consequences. It affects almost all spheres of life, i.e., personal, social, recreational, criminal, and family aspects; both physical and mental health; and economy of the society as well as the country. Advanced management and holistic prevention are public health priorities. However, very little attention has been paid to the issues as a region as well as in countries like Afghanistan, Bangladesh, and Pakistan. Hence, the editors of this book aimed to publish a book that discusses the public mental health and healthcare issues related to substance use disorder in a densely populated low- and middle-income setting.
Novel Formulations and Future Trends
Novel Formulations and Future Trends, Volume Three in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics with an original approach focused on technology, novelties and future trends. It discusses the most important developments in drug delivery, including important and exciting areas such as mucosal, implantable, transdermal, gastroretentive, vaccine and targeted drug delivery systems. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students. New technologies are also explored including 3D printing and computational pharmaceutics. - Explores the most recent technologies in drug delivery in detail - Contains contributions from the leading experts from academia, research, industry and regulatory agencies - Includes high quality illustrations, flow charts and tables for easy understanding of concepts - Discusses practical examples and research case studies
Immune Therapy for Pancreatic and Colon Cancers
Immune Therapy for Pancreatic and Colon Cancer expands the knowledge on pathways, immune modulators, immune check points, and monoclonal antibodies that can lead to appropriate cancer treatment. With a strong focus on the development of immune therapies to improve the survival rates of pancreatic and colon cancer, this book also shows the latest trends in immune targeted approaches for cancer treatment. Sections describe the role of and the immune response to pancreatic and colon cancer, gives insights to past and current immunotherapies, including metabolic reprogramming, immune blockade therapy and immune modulation.This book is a valuable resource for health professionals, scientists and ...
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer tria...
Detox Genes
Biotransformation is the metabolic conversion of endogenous and xenobiotic chemicals to more water-soluble compounds. Xenobiotic biotransformation is accomplished by a limited number of enzymes with broad substrate specificities. Liver is considered to be the main center of detoxification. The result of biotransformation in most cases is detoxification; nevertheless, metabolism of some xenobiotics produces metabolites more reactive than their substrate compound and leads to harmful changes. The biotransformation system involves several enzyme systems that are commonly divided into two phases. Phase I enzymes are responsible for oxidation, reduction or hydrolysis and can be either detoxifying...
