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Maggie Mars is a struggling screenwriter whose big break is happening now. Her latest script is being filmed and Maggie's on the set. But Maggie thinks that the lead actress is playing her character all wrong and tells her. A screaming match ensues. So when said actress is found dead with her head bashed in with her own Oscar, Maggie is viewed as a "person of interest". She tries to keep a low profile and cooperate with the police. Complicating things is the fact that one of the deputies on the case is a former lover of Joe Camanetti, the sometime/longtime love of Maggie's life. And somewhere out there is a killer who thinks Maggie is just too clever for her own good. Memo #312 to Maggie: Never write murder scenarios too good for a killer to pass up... At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is rega...
Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.
A diagnosis of lupus is understandably disquieting and can cause emotional turmoil. After all, there is no cure for the disease, and managing its debilitating symptoms can be challenging. This completely revised and updated edition of Coping with Lupusanswers all the important questions you may have about this disease of the autoimmune system. Writing in a warm, engaging style, Dr. Robert Phillips offers useful information and practical coping strategies to help you through a stressful time. He lends his expertise in dealing with the psychological aspects of chronic health problems, and provides the most recent medical information about lupus.
Most of the world's experts on prions met for a workshop in Erice in August 1996. The aim of the workshop was to discuss the fundamentals of the science ofprions. It was for tunate that so many could be present given the pressure that they were under because of the data presented in March 1996, indicating that Bovine Spongiform Encephalopathy, BSE or Mad Cow Disease, had penetrated the species barrier and was beginning to cause a new dis ease in humans--the new variant ofCreutzfeldt-Jakob Disease, nvCJD. This important and urgent subject became an additional major topic at the workshop. This is a book containing most of the talks plus the abstracts of those unable to find time to write up th...
Explore the fascinating world of sea monsters with this exciting guide to 50 aquatic cryptids by the creators of the bestselling Cryptid Creatures: A Field Guide. Cryptid Sea Monsters profiles 50 different aquatic cryptid mysteries around the world. Aspiring scientific explorers will discover that many ancient sea monsters turned out to be real creatures—like the oarfish, a real creature that inspired our legends about dragons—and learn about other cryptids that might one day turn out to be real. Each cryptid has a reality rating of 1 to 6 to show whether it's more of a hoax or something that has been discovered and recognized by science. This page-turning guide will inspire curious readers to investigate more on their own, and to understand the relationship between science and myth.
Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications.This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry,...
The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications....
Proceedings of a NATO ASI held in Rhodes, Greece, May 12-21, 1996