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Innovative Drug Synthesis
This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery
The South Western Reporter
Includes the decisions of the Supreme Courts of Missouri, Arkansas, Tennessee, and Texas, and Court of Appeals of Kentucky; Aug./Dec. 1886-May/Aug. 1892, Court of Appeals of Texas; Aug. 1892/Feb. 1893-Jan./Feb. 1928, Courts of Civil and Criminal Appeals of Texas; Apr./June 1896-Aug./Nov. 1907, Court of Appeals of Indian Territory; May/June 1927-Jan./Feb. 1928, Courts of Appeals of Missouri and Commission of Appeals of Texas.
Winston County, Alabama Cemeteries, Volume 1
The cemeteries of Winston County contain the ancestors of the descendants who populate the county. They contain the remains of the earliest settlers, Civil War soldiers, early county officials and politicians, merchants, tradesmen, farmers, and their familes. Without their successful efforts to carve an existence out of the Winston County wildnerness, the rest of us would not be here. Much of the history of the county was written on the old tombstones found across the county. Volume I of this two volume series alphabetically covers Winston County Cemeteries A through L beginning with the Addison Church of God Cemetery and ending with the Liberty Grove Missionary Baptist Church Cemetery. The book contains dozens of pictures of the cemeteries plus hundreds of annotations which include sites of unmarked graves mentioned in newspaper accounts plus the company and unit of every known Civil War era soldier, both Union and Confederate. The book concludes with a full name index.
Comprehensive Medicinal Chemistry III
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
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