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Epigenetic and Metabolic Regulators of Breast Carcinogenesis
Breast cancer is the most common tumor in females worldwide. Cancer epigenetics and metabolic reprogramming are known cancer hallmarks. Recent advances in the field of epigenetics include histone modification, DNA methylation, and non-coding RNAs. In contrast to genetic modifications, epigenetics refers to a set of dynamic alterations. By controlling the on and off states of oncogenes and tumor suppressor genes, as well as re-engineering the tumor microenvironment, epigenetics plays a crucial role in the initiation and progression of carcinogenesis. Additionally, the complex process of metabolic reprogramming is required for both malignant transformation and tumor development, including invasion and metastasis. Furthermore, reprogrammed metabolic activities have been utilized to diagnose, monitor, and treat cancer patients. In tumor tissues, metabolic heterogeneity was found to take a role in the adaptation to the microenvironment drastic changes resulting from current therapeutic modalities.
Trinacrime
TRINACRIME - Story of a Mafia Repentant, by Alessandro VizzinoThis is the story, in novel form, of one of the most relevant exponents of Catania's "Cosa Nostra" in the 1980s and 1990s. TRINACRIME - Story of a Mafia RepentantCatania, San Cristoforo neighborhood, early 1970s. Tonio is the son of a shoemaker, which is why they call him "lu Scarparu." Even as a child, he is a rebel with little interest in school and is more drawn to petty theft. His bravado and desire for freedom lead him to leave Catania to escape to Milan. There he is initiated into robbery and experiences his first prison term.Back in Catania, he acts with his gang, pulling off several hits that put him ingood standing with t...
Bollettino
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Italians to America, March 1904 - May 1904
Italians to America is the first indexed reference work devoted to Italian immigrants to the United States. This series contains passenger list information in chronological order on the first major wave of Italian migration during the last two decades of the nineteenth century, as well as the beginning of the twentieth century. As with the highly regarded companion series on German immigrants, Italians to America presents the passenger lists in chronological order, including information on each person's age, sex, occupation, village of origin, and destination, plus the name of the ship, the port of embarkation, and the date of arrival. Each volume also contains an introduction on the history of Italian migration to the U.S. and a full name index, greatly simplifying the researcher's job.
