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More than for any other volume of the Handbook of Neurochemistry, the chap ters in this volume on Pathological Neurochemistry deal with the interface of the laboratory bench with the patient's bedside. Most of the chapters reflect the confluence of basic scientists, clinical investigators, and physicians. Con sidered here are many of the more important disorders that afflict the nerves, muscles, spinal cord, and/or brain of mankind throughout the world. There are well over 500 such disorders. And our understanding of their nature and of measures for effective prevention or treatment depends significantly on appli cation of the biochemical disciplines that characterize neurochemistry. Before ...
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This book explores, for the first time, the clinical relevance of kindling. A number of conditions including epilepsy, and manic depressive psychosis and additional states in which a process similar to kindling may be of importance are highlighted. In addition, the possible implications of the kindling hypothesis of neuropsychiatric disorders are fully explored. This book offers a fascinating insight into current thinking and will serve as an invaluable reference source.