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Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.
An examination of postwar medicine based on the notion of the biomedical platform--the theoretical and clinical meeting ground between the normal and the pathological.
First multi-year cumulation covers six years: 1965-70.
Advances made so far in the worldwide study of AIDS and HIV owe much to our knowledge of T-cell leukaemia, which is the first human cancer known to be caused by a retrovirus. This book records the state-of-the-art findings on ATL and related diseases, and reviews the information which has been accumalated over the past two decades. Contributions from leading experts cover haematology, neurology, virology, epidemiology, pathophysiology, animal models, and treatment of ATL. The major contribution of ATL research to the understanding of AIDS, another retrovirus-caused disease, is clearly highlighted in this book. Contents include: ATL and HTLV-I-related diseases; regulation of HTLV-I-gene expression and its roles in ATL development; epidemiology of HTLV-I and HTLV-II infection; ethnoepidemiology of ATL in Japan, with special reference to mongoloid dispersal; ATL of Caribbean origin; molecular epidemiology of HTLV-I and HTLV-II; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP); pathophysiology of ATL cells; cell growth characteristics; animal models of HTLV-1 infection; chemotherapy of ATL, and new approaches to the treatmant of ATL.
Presents the current knowledge of the biology and immunology of chronic lymphocytic leukemia (CLL) and how it relates to the pathogenesis, diagnosis and oratory and therapy of this common form of leukemia - focusing on laboratory and clinical research and the state-of-the-art approach to patients with CLL. immunity in CLL, evaluates the immunologic and therapeutic implications of cross-reactive idiotypes in CLL and provides evidence for clonal evolution and its clinical relevance. Referenced with nearly 1650 bibliographic citations, this book should prove a valuable resource for oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists and molecular biologists.