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Toxicology of Glutathione Transferases
Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
Redox and Cancer Part A
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics — Volume 122 explores subjects related to redox, including: redox homeostasis in epithelial-derived cancers; reactive oxygen species in normal and tumor stem cells; and gamma-glutamyl transpeptidase and redox regulation. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students
Cancer Drug Resistance
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Mitochondria in Health and Disease
Mitochondrial biology reinvented itself and became a new world that has attracted new scientists influencing every field of biomedical research. Mitochondrial research is growing and changing, as reflected by the exponential rise in the number of conferences covering mitochondrial biology and the role of mitochondria in diseases ranging from neurodegenerative diseases,metabolic diseases and genetic muscular dystrophies toimmunopathologies and cancer. As the awareness of the essential role of mitochondria in pathology rose, a demand for new approaches to measure mitochondrial function resulted in the robust development of new forms of microscopy and spectroscopy that opened windows into previ...
Cancer Immunology
The rapid flow of studies in the field of cancer and immunology during the last decades has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it has been well-known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the crosstalk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. The Handbook of Cancer and Immunology offers a comprehensive and up-to-date review of cancer immunology and immunotherapy, emphasizing key findings and clinically relevant data. This reference work is an essential resource for researchers, students, academics, and clinicians committed to advancing knowledge, diagnostics, and treatments in this vital field.
Nanoscale Biophysics of the Cell
Macroscopic cellular structures and functions are generally investigated using biological and biochemical approaches. But these methods are no longer adequate when one needs to penetrate deep into the small-scale structures and understand their functions. The cell is found to hold various physical structures, molecular machines, and processes that require physical and mathematical approaches to understand and indeed manipulate them. Disorders in general cellular compartments, perturbations in single molecular structures, drug distribution therein, and target specific drug-binding, etc. are mostly physical phenomena. This book will show how biophysics has revolutionized our way of addressing the science and technology of nanoscale structures of cells, and also describes the potential for manipulating the events that occur in them.
Phytochemicals
Among the thousands of naturally occurring constituents so far identified in plants and exhibiting a long history of safe use, there are none that pose - or reasonably might be expected to pose - a significant risk to human health at current low levels of intake when used as flavoring substances. Due to their natural origin, environmental and genetic factors will influence the chemical composition of the plant essential oils. Factors such as species and subspecies, geographical location, harvest time, plant part used and method of isolation all affect chemical composition of the crude material separated from the plant. The screening of plant extracts and natural products for antioxidative and antimicrobial activity has revealed the potential of higher plants as a source of new agents, to serve the processing of natural products.
Cancer Research
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Current Trends in Green Nano-emulsions
This book gives a complete overview of current developments on the green synthesis and extraction of nano-emulsions for numerous uses in food, agriculture, biomedical, and cosmetics sectors. In the food and agriculture section, the book demonstrates the use of nano-emulsions to deliver nutraceuticals, coloring, and flavoring agents, in the development of biodegradable coating, improving the quality of packing films and enhancing the shelf life and nutritional value of foods. It also shows that nano-emulsions are very good for pesticides formulation where it enhances the solubility of poorly water-soluble pesticides, resulting in increased pesticide bioactivity compared to conventional pestic...
Canadian Medical Directory
A biographical listing of physicians practicing in Canada. Data includes name, address, university, graduation date, degrees, specialist certificates, and field of practice. Includes information pertaining to the practice of medicine in Canada including organizations, boards, and a listing of hospitals and universities.
