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This volume serves as a follow-up to our previous book, MonoclonalAntibodies Hybridomas: A New Dimension in Biological Analyses. We continue the theme of monoclonal antibodies and their applications, attempting to cover some of the areas not covered in the previous volume. We again include an appendix de scribing methods useful to those who ar-e beginning to apply these techniques in their own laboratories. This volume will be followed by another concentrating on the combination of monoclonal antibody techniques with molecular genetic techniques to study structure/function relationships at the level of both the gene and gene product. Roger H. Kennett Kathleen B. Bechtol Philadelphia, Pennsyl...
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Once considered largely untreatable, neurologic disorders have become the newest frontier for breakthrough research in pharmacology. Principles of Drug Therapy in Neurology discusses the latest investigatinal strategies and theories and how they affect current clinical practice. The book details the mechanisms, delivery systems, and efficacy of the latest medication, as the editors outline a "method" for thinking about the action of clinically useful drugs, based on modern information about kinetics, transport to the brain, interaction with neurotransmitter systems and membrane action, etc. All types of major neurologic disorders are discussed.
Myasthenia gravis is the best-understood autoimmune disorder and its intense investigation has provided insights into the pathogenesis of autoimmune disease in general and the basic mechanisms of synaptic transmission. The papers in this volume report research findings on the mechanisms of disease, diagnosis and treatment of myasthenia gravis and related diseases. Other papers examine the advances in knowledge about the physiology, biochemistry, genetics, and the structure of the neuromuscular junction as well as advances in the immunology of pre-and post-synaptic disorders of the junction. Papers also discuss the clinical management of myasthenia gravis and related disorders.
This work on the neurosciences presents an update on normal physiological mechanisms at the neuromuscular junction, normal immune responses as these relate to auto-immunity, and pathogenic mechanisms responsible for myasthenia (the prototype human auto-immune disease), along with diagnostic and therapy information.