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The Picornaviruses
A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. • Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. • Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.
A Survey of Attitudes and Actions on Dual Use Research in the Life Sciences
The same technologies that fuel scientific advances also pose potential risks-that the knowledge, tools, and techniques gained through legitimate biotechnology research could be misused to create biological weapons or for bioterrorism. This is often called the dual use dilemma of the life sciences. Yet even research with the greatest potential for misuse may offer significant benefits. Determining how to constrain the danger without harming essential scientific research is critical for national security as well as prosperity and well-being. This book discusses a 2007 survey of American Association for the Advancement of Science (AAAS) members in the life sciences about their knowledge of dua...
Defence Against Bioterrorism
This volume is based on a multidisciplinary approach towards biological and chemical threats that can, and have been previously used in bioterrorism attacks around the globe. Current knowledge and evidence-based principles from the fields of synthetic biology, microbiology, plant biology, chemistry, food science, forensics, tactics, infective medicine, psychology and others are compiled to address numerous aspects and the complexity of bioterrorism attacks. The main focus is on biological threats, especially in the context of synthetic biology and its emerging findings that can be observed as possible threat and tool. The book examines microorganisms and their possible use in forensics, i.e....
New Vaccines and Chemotherapy
Viral Vaccines Joseph L. Melnick As with history in general, the history of vaccines needs to be reexamined and updated. My task is to look back to see what has been successful and to look forward to see what remains to be accomplished in the prevention of viral diseases by vaccines. Also, I shall refer to the pertinent material discussed at two recent conferences of the Institute of Medicine, National Academy of Sciences, on virus vaccines under development and their target populations in the United States (1985b) and in developing countries (1986). These reports, plus a third on Vaccine Supply and Innovation (1985a), should be required reading for all those in both the public and the priva...
Phantom Menace or Looming Danger?
The horrifying terrorist attacks on September 11, 2001, and the anthrax strikes that soon followed gave the United States new reason to fear unconventional enemies and atypical weapons. These fears have prompted extensive research, study, and planning within the U.S. military, intelligence, and policy communities regarding potential attacks involving biological weapons. In Phantom Menace or Looming Danger?, Kathleen M. Vogel argues for a major shift in how analysts assess bioweapons threats. She calls for an increased focus on the social and political context in which technological threats are developed. Vogel uses case studies to illustrate her theory: Soviet anthrax weapons development, th...
Polio
Discusses the history of the poliovirus, its effects on the body, vaccines and the researchers who discovered them, and the threat that this virus still poses.
Principles of Virology
Completely revised and updated to reflect important advances in the field, Principles of Virology, Second Edition continues to fill the gap between simple introductory texts and very advanced reviews of major virus families, introducing upper–level undergraduates, graduate students, and medical students to all aspects of virology. The second edition retains all of the defining and much–praised features of the first edition, focusing on concepts and principles and presenting a comprehensive treatment from molecular biology to pathogenesis and infection control. Written in an engagingly readable style and generously illustrated with over 400 full–color illustrations, this approachable vo...
Genome Research in Molecular Medicine and Virology
Reviews the application of the techniques of molecular genetics and molecular biology to biomedical research. Among the subjects discussed are normal and abnormal chromosomes, cancer, hereditary disorders, model genome systems and molecular virology.
