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The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulatin...
Source control is the key to the management of surgical infections. Surgical decision making is based on the marriage of evidence from clinical studies, inferences from biology, and the elusive component of surgical experience; this book combines these three elements. We have recruited an international group of authors who are acknowledged leaders in the field of surgical infectious diseases. We have challenged them to integrate evidence with experience and an understanding of biology so as to create overviews that will help the clinician who must make the difficult decisions. And we have kept them honest by asking a second group of equally eminent commentators to provide supporting or alternative views - in essence, to recreate the kind of dialogue that takes place between clinicians discussing a difficult problem. This is THE manual for the authoritative management of surgical infections!
Describes the common complications associated with trauma and critical care and specific information about their management. Organized in readily accessible sections, with thorough reference citations and pertinent illustrations. Major sections include: systemic complications; head, neck, and neurotrauma complications; cardiovascular and thoracic injury complications; abdomen and alimentary tract complications; complications of orthopaedic trauma; the burn victim; and the pregnant and pediatric trauma victims.
The classic trauma surgery text! This comprehensive and authoritative reference text covers prevention and pre-hospital care transport through trauma "scoring" as well as operative and non-operative management. Known for its current and practical coverage, the book features a commentary for each chapter written by a leading expert in the field.