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Biomedical Technology
During the last years computational methods lead to new approaches that can be applied within medical practice. Based on the tremendous advances in medical imaging and high-performance computing, virtual testing is able to help in medical decision processes or implant designs. Current challenges in medicine and engineering are related to the application of computational methods to clinical medicine and the study of biological systems at different scales. Additionally manufacturers will be able to use computational tools and methods to predict the performance of their medical devices in virtual patients. The physical and animal testing procedures could be reduced by virtual prototyping of medical devices. Here simulations can enhance the performance of alternate device designs for a range of virtual patients. This will lead to a refinement of designs and to safer products. This book summarizes different aspects of approaches to enhance function, production, initialization and complications of different types of implants and related topics.
Modelling Congenital Heart Disease
This book combines medicinal and engineering knowledge to present engineering modelling applications (mainly computational, but also experimental) in the context of facilitating a patient-centred approach to treating congenital heart disease (CHD). After introducing the basic concepts of engineering tools, it discusses modelling and the applications of engineering techniques (e.g. computational fluid dynamics, fluid-structure interaction, structural simulations, virtual surgery, advanced image analysis, 3D printing) in specific congenital heart diseases. It also offers a number of clinical case studies describing the applications in real-life clinical practice. The final section focuses on t...
Edge-to-Edge Mitral Repair
This is the first comprehensive review of the edge-to-edge technique for mitral repair, which was introduced into the surgical armamentarium in 1991 by one of the authors, Ottavio Alfieri. The surgical technique employed in edge-to-edge repair today provides the basis for the only reliable method of percutaneous correction of degenerative mitral regurgitation. The book traces the evolution of the edge-to-edge technique from a surgical to a percutaneous approach, documenting indications, contraindications, technical aspects, controversies and clinical outcomes. Detailed attention is devoted to the MitraClip procedure, which reproduces the Alfieri stitch percutaneously and has to date been use...
Statistics for Innovation IV
This book presents peer-reviewed short papers on methodological and applied statistical research presented at the Italian Statistical Society’s international conference on “Statistics for Innovation”, SIS 2025, held in Genoa, Italy, June 16-18, 2025. It is the last of four volumes, featuring the third part of the contributions presented in the Contributed Sessions. Providing a comprehensive overview of innovations in modern statistical methods and applications, the volumes address a large number of topics of current interest, contributing to a rapid dissemination of quantitative methods for data analysis across the various fields of scientific research and social life. The volumes unde...
