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Prognostic and Predictive Factors in Autoimmune Connective Tissue Disorders
Autoimmune connective tissue diseases, including systemic lupus erythematosus, Sjögren’s syndrome, systemic sclerosis, dermatomyositis, rheumatoid arthritis, and mixed connective tissue diseases are complex conditions that commonly involve multiple organs and systems. The pathogenesis of many autoimmune diseases is elusive, and the disease course is extremely variable, with indolent or rapidly progressive case subsets. The heterogeneity and patient-to-patient variability of autoimmune connective tissue disease extend to their clinical manifestations, autoantibody profiles, speed of disease progression, the constellation of target organ effects, response to treatment, and survival. Despite...
The Third Lens
Does science aim at providing an account of the world that is literally true or objectively true? Understanding the difference requires paying close attention to metaphor and its role in science. In The Third Lens, Andrew S. Reynolds argues that metaphors, like microscopes and other instruments, are a vital tool in the construction of scientific knowledge and explanations of how the world works. More than just rhetorical devices for conveying difficult ideas, metaphors provide the conceptual means with which scientists interpret and intervene in the world. Reynolds here investigates the role of metaphors in the creation of scientific concepts, theories, and explanations, using cell theory as...
Scientific Report
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The First Outstanding 50 Years of “Università Politecnica delle Marche”
The book describes the significant multidisciplinary research findings at the Università Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today’s fast-growing, global society and the changes it has caused. It also discusses solutions to improve the wellbeing of human beings. The book covers the main research achievements in the various disciplines of the life sciences, and includes chapters that highlight mechanisms relevant to all aspects of human diseases, the molecular, cellular, and functional basis of therapy, and its translation into the management of people’s health needs. It also describes research on tradition...
