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For both volumes: Expert investigators describe not only the classic methods, but also the many novel techniques they have perfected for the transfer of large DNAs into the cells of both microbes and animals via large-insert recombinant DNAs. Volume 1 presents readily reproducible techniques for library construction, physical mapping, and sequencing.. An accompanying volume, Volume 2: Functional Studies, provides a wide variety of methods and applications for functional analysis of the DNA-transformed organisms. Besides protocols, each chapter includes scientific reviews, software tools, database resources, genome sequencing strategies, and illustrative case studies.
Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as...
'How to be Good?' is the pre-eminent question for ethics, although one that philosophers and ethicists seldom address head on. Knowing how to be good, or perhaps (more modestly and more accurately) knowing how to go about trying to be good, and the ways in which it is pointless or self-defeating to try to be good, is of immense theoretical and practical importance. And what goes for trying to be good oneself, goes also for trying to provide others with ways of being good, and for trying to make them good whether they like it or not. This is what is meant by 'moral enhancement'. There are many proposed methodologies or technologies for moral enhancement. Some of them are ancient and/or famili...
This comprehensive handbook synthesizes the often-fractured relationship between the study of biology and the study of society. Bringing together a compelling array of interdisciplinary contributions, the authors demonstrate how nuanced attention to both the biological and social sciences opens up novel perspectives upon some of the most significant sociological, anthropological, philosophical and biological questions of our era. The six sections cover topics ranging from genomics and epigenetics, to neuroscience and psychology to social epidemiology and medicine. The authors collaboratively present state-of-the-art research and perspectives in some of the most intriguing areas of what can b...
Produced in Italy from the turn of the 20th century, "sword and sandal" or peplum films were well received in the silent era and attained great popularity in the 1960s following the release of Hercules (1959), starring Mr. Universe Steve Reeves. A global craze for Bronze Age fantasy-adventures ensued and the heroic exploits of Hercules, Maciste, Samson and Goliath were soon a mainstay of American drive-ins and second-run theaters (though mainly disparaged by critics). By 1965, the genre was eclipsed by the spaghetti western, yet the 1960s peplum canon continues to inspire Hollywood epics. This filmography provides credits, cast and comments for dozens of films from 1908 through 1990.
Investigations into the interplay of biological and legal conceptions of life, from government policies on cloning to DNA profiling by law enforcement. Legal texts have been with us since the dawn of human history. Beginning in 1953, life too became textual. The discovery of the structure of DNA made it possible to represent the basic matter of life with permutations and combinations of four letters of the alphabet, A, T, C, and G. Since then, the biological and legal conceptions of life have been in constant, mutually constitutive interplay—the former focusing on life's definition, the latter on life's entitlements. Reframing Rights argues that this period of transformative change in law ...
Includes entries for maps and atlases.