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Chemosensitivity Testing in Oncology
Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well...
Acute Leukemias IV
The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome tr...
Acute Leukemias VII
With contributions by numerous experts
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Chemistry and Biology of Pteridines and Folates
These papers are the proceedings of the International Symposium on the Chemistry and Biology of Pteridines and Folates. The book brings together contributions from some 250 scientists from chemistry, biochemistry, biology, pharmacology, and medicine to present and discuss recent advances in this expanding field. Pteridines fulfil many roles in nature, ranging from pigments to essential co-factors for numerous redox and carbon transfer reactions. This large diversity of function is unified by the unique chemistry of the pteridine heterocycle. Emphasis in the book is given to: the progress of antifolates in cancer therapy, with emerging new compounds of broad range effectiveness and with gene therapeutic approaches; on the role of folates in nutrition and their pathological changes; and on new findings in pteridine and folate enzymes.
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Biobehavioral Stress Response
Papers from a September 2003 meeting provide an opportunity to examine many of the popular assumptions about the biologic components of the stress response that confer distress or are likely to culminate in mental or physical pathology, and to replace these assumptions with findings that suggest a far more complex model of stress. The book draws attention to the lack of uniform biological and behavioral responses to stress, focusing instead on the multifaceted attributes of stressors and individual vulnerability and protective factors. There is no subject index. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com).
Recent Advances in Cell Biology of Acute Leukemia
The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints ...
Dictionary of International Biography ...
A biographical record of contemporary achievement together with a key to the location of the original biographical notes.
