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Transcription Factor Protocols
The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal promoter elements, and distal enhancer elements. General initiation factors are involved in positioning RNA...
From DNA Photolesions to Mutations, Skin Cancer and Cell Death
As modern day society takes an increasing interest in outdoor activities, its exposure to sunlight has never been greater. As a consequence, countries throughout the world are experiencing a dramatic increase in the incidences of skin carcinomas and melanomas. From DNA photolesions to mutations, skin cancer and cell death provides an authoritative source of information for photobiologists interested in the series of genetic events that occur in the skin, and eventually lead to cancer. With contributions from eminent scientists in the field, this book includes the latest information on DNA photolesions and repair, as well as the key mechanisms of solar UV in skin cancer initiation and development. Significant information relating to UV-induced photolesions and mechanisms of skin tumour occurrence is also included. By providing the basic phenomena underlying the science and an overview of the biological events that take place when cells are exposed to solar UV radiation, From DNA photolesions to mutations, skin cancer and cell death is suitable to all researchers interested in the process of photocarcinogenesis.
Progress in Nucleic Acid Research and Molecular Biology
- Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology - Features contributions from leaders in their fields - Contains abundant references
DNA and Nucleoprotein Structure in Vivo
This book is about the structural aspects of nucleic acids in vivo and interactions between proteins and DNA in living cells. It provides an overview of the techniques involved by which the study of native genomes has been greatly facilitated. It also gives a description of the mode of action of many different DNA modifying agents which can be used for such studies. Furthermore, it describes the limitations of the currently existing techniques, includes some relevant applications and shows potential future developments. This book is recommended for anyone interested in the qualitative and quantitative study of native genomes.
Cancer Research
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Gene Expression
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Epigenetic Mechanisms of Gene Regulation
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
DNA Damage
The focus of this collection of papers is upon the perturbations which damage introduces into DNA molecules, and how these structural changes influence the recognition and interactions of biologically important proteins with damaged DNA.
