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Presents not only the major principles and current issues in the field but also provides a physiologic basis for the actions and reactions to reproductive toxic agents. The volume is divided into three sections. The first focuses on the current concepts of normal mammalian reproductive function from the systems to subcellular level. The second explains how toxic substances disrupt the normal functioning of elements of the mammalian reproductive system. The third section discusses other issues of long-standing or recent interest to the field, such as clinical aspects, epidemiology, and the toxic effects of low-energy electromagnetic fields and tobacco, alcohol, and other substances of abuse. Annotation copyright by Book News, Inc., Portland, OR
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One of the most popular areas in toxicology is environmental toxicology & its effects on human fertility. Designed as a clinical reference, this book focuses on both the mechanisms of reproductive failure (male & female) & the clinical techniques for assessing & monitoring the effects of various toxicants on the reproductive process. Section I provides a basic overview of the toxicologic effects of various agents on male & female reproductive physiology & the process of conception. Section II builds on this background & covers the mechanisms of toxicant action, describing the ways in which normal reproduction may become deranged. Section III describes clinical & epidemiological methods by which fertility can be monitored & by which reproductive toxicity might be identified.
"This volume of the IARC Monographs provides evaluations of the carcinogenicity of shiftwork, painting and firefighting. Shiftwork is estimated to involve about 15-20% of the total working population. It is most prevalent among workers in the health care, transportation, communication, leisure and hospitality sectors. Shiftwork involving work at night is the most disruptive for the circadian clock. Painters are potentially exposed to the chemicals found in paint products during their application and removal, and may also be exposed to other workplace hazards, such as asbestos or crystalline silica dust. Firefighters may be exposed at different intensity levels depending on crew assignment, tasks, and/or the time spent at fires. All fires generate a very large number of toxic combustion products, including known, probable or possible carcinogens. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays where appropriate, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard of these three exposure circumstances to humans."--Books.google.