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This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristic...
Vascular diseases of the retina are a major cause of blindness among all age groups. Edited and written by internationally well-known experts, this state-of-the-art comprehensive overview of basic and clinical science will enhance the understanding of retinal vascular disease and help in the evaluation of current and future treatment approaches for the clinician. The well-structured and highly illustrated text is divided into three easy-to-follow sections. This unique textbook-atlas also includes topics which are not currently found in other retinal disease textbooks, such as case reports and clinical follow-ups.
Diabetic retinopathy is the most common microvascular complication of diabetes. It remains a major cause of new-onset visual loss in the United States and other industrialized nations. In Diabetic Retinopathy, Elia Duh and a panel of internationally recognized experts comprehensively assess the current state of knowledge regarding the clinical management of DR as well as its underlying mechanisms. The authors outline the current understanding of diabetic retinopathy from the perspective of clinical practice, while reviewing the multi-factorial pathogenesis and pathophysiology of DR from the standpoint of biomedical research. Also included is a discussion of emerging concepts relating to the management and treatment of DR. Informative and highly-practical, Diabetic Retinopathy provides ophthalmologists, diabetologists, endocrinologists, and internists with a highly readable guide not only to understanding diabetic retinopathy, but also to its optimal clinical management.
Water Management Challenges in Global Change contains the proceedings of the 9th Computing and Control for the Water Industry (CCWI2007) and the Sustainable Urban Water Management (SUWM2007) conferences. The rationale behind these conferences is to improve the management of urban water systems through the development of computerbased methods. Issues such as economic globalisation, climate changes and water shortages call for a new approach to water systems management, which addresses the relevant technical, social and economic aspects. This collection represents the views of academic and industrial experts from a number of countries, who provide technical solutions to current water managemen...
These proceedings not only summarized the scientific and technological achievements in atherosclerosis research during the 20th century but also include the latest topics for future progress and development in this new millennium, highlighting the recent advances in vascular biology, angiogenesis and atherogenesis, pathogenesis of metabolic syndrome. The articles also encompass vast range of clinical and basic research field of atherosclerosis, including epidemiology, lipoprotein metabolism, pharmacology, clinical trials, nutrition, pathogenesis, diagnosis and prevention as well as its treatment.
The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag's first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the mo...
The role of the Maillard reaction in diabetes and its complications has led to a better understanding of the importance of oxidative stress, lipid peroxidation, and hyperlipidemia in diabetic complications. This volume addresses all of these issues and highlights current research trends.
Proceedings of an October 2000 conference held in Japan exploring the current state of glycobiology in the medical fields. Thirty-nine contributions, primarily by Japanese researchers, are arranged in sections on metabolism of glycolipids, sialic acid and pathology; roles of N-glycans in tissues; mucin as a biogenic messenger; roles of proteoglycans in tissue organization; and new developments of glycosaminoglycans for clinical applications. A sampling of topics: catabolism of GM2 in man and mouse, transcriptional control of mammalian sialidase genes, the chemical structure of the carbohydrate moiety of fucose-rich glycopeptides from human pancreatic juice, MUC1 as a human tumor marker, functional analysis of cellulose-synthase- like genes, the rationale for and pre-clinical results of chondroitinase ABC in chemonucleolysis, and enzymatic reconstruction of glycosaminoglycan oligosaccharides. Annotation copyrighted by Book News Inc., Portland, OR.