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Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions
Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
Targeted Cancer Immune Therapy
Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the n...
Ferroptosis: Mechanism and Diseases
This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
Non B cell-Derived Immunoglobulins
This book has expanded classic concept of immunology. Immunoglobulins have been widely discovered to be produced by many non-B cells. The non B cell-derived Igs display multifunction, which not only includes antibody activities and cellular biological functions under physiological conditions, but also directly participate in the pathological process of malignant tumour and immune-related diseases. This book provides new perspectives and a solid foundation for medical students, basic and clinical scientists to re-understand and broaden the physiological and pathological significance of Ig.
Molecular Mechanisms of Programmed Cell Death
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner, H. Robert Horvitz, and John E. Sulston for their seminal discoveries concerning "genetic regulation of organ development and programmed cell death." This clearly marked the prime importance of understanding the molecular mechanisms controlling cell death. The 1 st International Symposium on Programmed Cell Death was held in the Shanghai Science Center of the Chinese Academy of Sciences on September 8-12, 1996. A number of key issues in apoptosis were discussed at the meeting, and progress in major areas of apopto sis research was summarized by expert participants at the meeting and published by Plenum Publishing Corporation as a book entitled Programmed Cell Death. In the last six years, we have witnessed a real explosion in our knowledge on how cells undergo apoptosis, thereby participating in various developmental and pathophysiological processes. At this ever exciting time, we organized the 2nd International Symposium on Programmed Cell Death.
GeNeDis 2022
The 5th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Neuroscientific Advances.
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
