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Coherent X-ray diffractive imaging on the single-cell-level of microbial samples
Since its first experimental demonstration in 1999, Coherent X-Ray Diffractive Imaging has become one of the most promising high resolution X-Ray imaging techniques using coherent radiation produced by brilliant synchrotron storage rings. The ability to directly invert diffraction data with the help of advanced algorithms has paved the way for microscopic investigations and wave-field analyses on the spatial scale of nanometres without the need for inefficient imaging lenses. X-Ray phase contrast which is a measure of the electron density is an important contrast mode of soft biological specimens. For the case of many dominant elements of soft biological matter, the electron density can be c...
Energy Systems Optimization Considering the Uncertainty of Future Developments
In light of anthropogenic climate change and the importance of energy to ensure high living standards, energy system optimization is used to explore different energy system layouts. A recent focus has been on determining cost-effective ways to mitigate greenhouse gas emissions. This work investigates how future uncertainties regarding technology costs influence optimization results. This is achieved through energy system optimization aimed at reducing system cost using stochastic optimization with probability distributions to capture expected future costs and uncertainties. Theoretical considerations and a minimal example energy system show that Jensen's inequality leads to an overestimation...
Using Genomics, Metagenomics and Other "Omics" to Assess Valuable Microbial Ecosystem Services and Novel Biotechnological Applications
Most ecosystem services and goods human populations use and consume are provided by microbial populations and communities. Indeed, numerous provisioning services (e.g. food and enzymes for industrial processes), regulating services (e.g. water quality, contamination alleviation and biological processes such as plant-microbial symbioses), and supporting services (e.g. nutrient cycling, agricultural production and biodiversity) are mediated by microbes. The fast development of metagenomics and other meta-omics technologies is expanding our understanding of microbial diversity, ecology, evolution and functioning. This enhanced knowledge directly translates into the emergence of new applications...
Drug Discovery and Development, Third Edition
Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted tren...
Scandinavian Studies
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Zeitungsextrakte
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