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Studying the immune microenvironment of liver cancer using artificial intelligence
Liver cancer is ranked as the sixth most commonly diagnosed malignant primary tumor and the fourth main reason for cancer-related death in the world. Countless metastatic cascade steps are concealed in the microenvironment composed of the pivotal facets of the liver immune system. The immune microenvironment has a more crucial role than we thought it would. Current treatments may not only have difficulty achieving the desired therapeutic effect but also have obstacles with a higher recurrence rate. New thinking in hepatic carcinoma’s immune microenvironment is an urgent need. Digital intelligence has not only deepened the understanding of liver cancer but has also perpetually amended the t...
Experimental and Computational Methods in the Development of Diagnostics and Therapeutics for Colon Cancer
Cancer continues to be one of the major causes of illness and death worldwide. Cancer is growing at a shocking speed and touches every geographic region of the world. It is predicted that by 2030 there will be 21.7 million new cases and 13 million deaths. To overcome this problem efficiently and to make significant progress in cancer research and therapy, both the scientific and healthcare sectors must work together. Recent advancements in the development of AI-based methods i.e. ensemble or stacking algorithms to discover novel biomarkers using gene expression and other data provide greater opportunity for complete data analysis to decipher the mechanism of colon cancer initiation, progress...
Design and development of new therapeutics against infectious diseases using computational and experimental approaches
Infectious diseases are caused by bacteria, fungus, viruses, and other microorganisms. Biomolecules such as proteins, DNA, and/or RNA play a crucial role in the infections of these disorders. These infectious illnesses are often transmissible, meaning they may be passed from one person to another by a variety of means. Even though medical technology has progressed, some illnesses continue to cause anxiety among individuals worldwide. If we examine the situation of COVID-19, the entire world is terrified of the pandemic. Similarly, In the last decades, other infections including Dengue, Chikungunya, Zika, Ebola, Japanese Encephalitis Virus (JEV), influenza, the common cold, tuberculosis (TB), Hepatitis A and B and human immunodeficiency syndrome (HIV) have also challenged the human population.
The Involvement of Systemic Homeostasis in Tumour Biology
Systemic homeostatic mechanisms include several aspects, such as metabolic, neuroendocrine, immune, and physiological homeostasis. Irreversible damage or reversible imbalance of such homeostatic processes may initiate cancers by altering the regulation of the molecular machinery. Systemic homeostasis-related genes have been found to be intimately involved in oncological processes and in some instances have shown prognostic value. Thus, future gene targeting approaches for cancer should not only focus on classical cancer drivers but also address systemic homeostasis-related genetic mechanisms. Identification of systemic homeostasis-related genes with diagnostic, prognostic or therapeutic valu...
Roles of Gut Microbiota in Cancers of the Gastrointestinal Tract
The gut microbiota, comprised of a large population of microorganisms including bacteria, bacteriophages, fungi, and archaea interacting closely with the host, plays a major role in gut inflammation and tumorigenesis through direct cell-cell contact or secretion of bioactive substances. Shotgun metagenomic sequencing studies conducted in the last decade have revealed the widespread alterations of the microbial landscape in tumors of the gastrointestinal (GI) tract and, together with functional experiments, pinpointed specific microbes that functionally contribute to tumorigenesis. Altered gut microbiota is casually linked to GI cancers. In light of the increasingly appreciated association, s...
