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This work features 250 articles covering topics in molecular biology, molecular medicine and biotechnology. Each article has been carefully reviewed and is illustrated and referenced. Each subject is presented on a first-principle basis, including appropriate mathematics.
The increased interest in multiple forms of enzymes that began with the application of new methods of fractionation to preparations of enzymes and other proteins some 25 years ago led quickly to an appreciation that the existence of enzymes in multiple forms, or isoenzymes, is a general phenomenon. The results of pioneering studies and those which followed in the early years of isoenzyme research consisted, not surprisingly, mainly of descriptions of the existence and characteristics of hetero geneity in various enzyme systems. Summaries of these results were provided in books such as J . H. Wilkinson's I soenzymes, the first edition of which appeared in 1965. Some clearer ideas of the natur...
Isoenzymes were 'discovered' 20 years ago and were at first regarded as interesting but rare occurrences. Since then a wealth of information on enzyme heterogeneity has accrued and it now seems likely that at least half of all enzymes exist as isoenzymes. This is important in many areas of biological and medical science. Thus isoenzyme studies have provided the main experimental substance for the neutral drift controversy in genetics and evolution; they have greatly extended our understanding of metabolic regulation not only in animals but also in bacteria and plants; their existence has made available a multitude of highly sensitive markers for the study of differentiation and development, ...
Isoenzymes in Biology and Medicine attempts to give an account of the study of isoenzymes in relation to humans, animals, insects, higher plants, fungi, protozoa, algae, and bacteria. This book discusses the chemical structure, physiological aspects, metabolic role, and function of isoenzyme observations in genetic, ontogenic, and phylogenic studies. A detailed account of the use of isoenzyme in the diagnosis and pathogenesis of disease and control of therapy is also provided. This text likewise considers the isoenzymes of the oxidoreductases, transferases, and hydrolases, including its relation to clinical medicine. This publication is intended for biochemists, biologists, clinical biochemists and physicians.
Now in its Eighth Edition, this leading comprehensive manual helps nurses deliver safe, effective, and informed care for patients undergoing diagnostic tests and procedures. The book covers a broad range of laboratory and diagnostic tests and studies that are delivered to varied patient populations in varied settings. Tests are grouped according to specimen and function/test type (e.g. blood, urine, stool, cerebrospinal fluid, etc.). Each test is described in detail, with step-by-step guidance on correct procedure, tips for accurate interpretation, and instructions for patient preparation and aftercare. Clinical Alerts highlight critical safety information.