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First multi-year cumulation covers six years: 1965-70.
Nuclear Organization in Development and Disease
The nuclear envelope is the boundary between a cell’s nucleus and the surrounding cytoplasm, and consists of inner and outer membranes traversed by the nuclear pores. Underlying the inner nuclear membrane is a thin proteinaceous layer, the nuclear lamina, which comprises princiapally nuclear lamins - intermediate filament-type proteins. This envelope regulates several important processes: the traffic of molecules between the nucleus and the cytoplasm, nuclear morphology during the cell cycle, DNA synthesis and chromatin organization. Nine human diseases have been linked to mutations in genes encoding components of the nuclear envelope, mostly in the lamin A gene (LMNA). These diseases incl...
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