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Prognostic and Predictive Factors in Autoimmune Connective Tissue Disorders
Autoimmune connective tissue diseases, including systemic lupus erythematosus, Sjögren’s syndrome, systemic sclerosis, dermatomyositis, rheumatoid arthritis, and mixed connective tissue diseases are complex conditions that commonly involve multiple organs and systems. The pathogenesis of many autoimmune diseases is elusive, and the disease course is extremely variable, with indolent or rapidly progressive case subsets. The heterogeneity and patient-to-patient variability of autoimmune connective tissue disease extend to their clinical manifestations, autoantibody profiles, speed of disease progression, the constellation of target organ effects, response to treatment, and survival. Despite...
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