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Antibiotic Drug Discovery
Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities. Addressing the need for continued investment in antibiotic drug development, the book provides a point of reference for the rapidly expanding infectious disease research community. In addition to its attention on new targets, the book focusses on the medicinal chemistry and chemistry of the targets. Within this framework, chapters from leading researchers in academia and industry address findings in important areas such as biofilm production, narrow spectrum antibiotics and novel antibacterials from previously uncultured soil bacteria. This book will be a useful resource for postgraduate students and researchers in medicinal chemistry wishing to understand the latest approaches to antibiotic drug discovery.
Fragment-Based Drug Discovery
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
Innovations in Mechanical Engineering
This book covers a variety of topics in the field of mechanical engineering, with a special focus on methods and technologies for modeling, simulation, and design of mechanical systems. Based on a set of papers presented at the 1st International Conference “Innovation in Engineering”, ICIE, held in Guimarães, Portugal, on June 28–30, 2021, it focuses on innovation in mechanical engineering, spanning from engineering design and testing of medical devices, evaluation of new materials and composites for different industrial applications, fatigue and stress analysis of mechanical structures, and application of new tools such as 3D printing, CAE 3D models, and decision support systems. This book, which belongs to a three-volume set, provides engineering researchers and professionals with extensive and timely information on new technologies and developments in the field of mechanical engineering and materials.
Of Love and Faith
"I'm Zaki." Strange, but his voice echoed inside me in a similar fashion when one struck the bell in the church, the sound of it travelled through the walls of my ears and cascaded to my throat, then hit my rib cages and caused an unexpected jolt in my heart. If love's a destination, then the heart would know when one had finally arrived. In his arms I found home. But it's hard to understand the ways of fate. In the fantasy world of Disney, love is enough. In the real world of men and women, and at the time when people differ from each other, not just by races but also by beliefs, there are age-old traditions that cannot be bypassed by means of love. There are no fairy tales, there are few love stories and this one far from ordinary. At the core of this story are two hearts with differing faiths. The divide is as old as time, and the differences as complex as history itself.
Dictionary of International Biography
A biographical record of contemporary achievement together with a key to the location of the original biographical notes.
The College
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