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Growth and nutrition during the fetal period and the first 24 months after birth are important determinants of development in early childhood. Optimal nutrition and health care of both the mother and infant during these first 1000 days of an infant's life are closely linked to growth, learning potential and neurodevelopment, in turn affecting long-term outcomes. Children with low birth weight do not only include premature babies, but also those with intrauterine growth restrictions who consequently have a very high risk of developing metabolic syndrome in the future. Epidemiology, epigenetic programming, the correct nutrition strategy and monitoring of outcomes are thus looked at carefully in this book. More specifically, two important nutritional issues are dealt with in depth: The first being the prevention of low birth weight, starting with the health of adolescent girls, through the pre-pregnancy and pregnancy stages and ending with lactation. The second point of focus concerns the nutritional follow-up and feeding opportunities in relation to dietary requirements of children with low birth weight.
The National Academies of Sciences, Engineering, and Medicine last reviewed the state of the science on nutrition during pregnancy and lactation 30 years ago. The resulting consensus study reports from the Institute of Medicineâ€"Nutrition During Pregnancy (IOM, 1990) and Nutrition During Lactation (IOM, 1991)â€"summarized the scientific evidence and provided nutrient recommendations. In the decades since the release of these two reports, the body of evidence on the relationships between nutrition during pregnancy and lactation and maternal and infant health and chronic disease has continued to grow and evolve. At the same time, the demographics of the population have shifted, giving rise to new considerations. To explore the evidence that has emerged, the National Academies conducted a 2-day workshop in January 2020. This publication summarizes the presentations and discussions from the workshop.
Early and adequate nutritional support is critical to achieve appropriate rates of weight gain, which are almost twice that of a term infant. The 96th Nestlé Nutrition Institute Workshop was focused on the latest scientific knowledge in the area of neonatal care in preterm and low-birth-weight infants, including human milk oligosaccharides (HMOs) and their potential impact on the health of neonates. This 3-session workshop facilitated interactions between international experts. The first session, chaired by Prof. Nick Embleton, looked at optimizing feeding, nutrition, and growth in the neonatal intensive care unit and after discharge. Prof. Ferdinand Haschke chaired the second session, which looked at the personalized nutrition of preterm infants. The third session, chaired by Lars Bode, looked at the role of HMOs and the microbiome in the health of term and very-low-birth-weight infants. The key issues provided by this 3-day workshop offer valuable insights for healthcare providers, policy makers, and researchers on the crucial role of proper nutrition for adequate growth and consequent development of preterm infants.
Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system. This publication deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity.The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense. Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest.
When developing a new product, many obstacles have to be overcome from the idea to the shelf: know-how from different subject areas is called for to create a product that is not only technically feasible, but also complies with regulations and meets consumer needs and preferences. This book addresses and tries to identify forces that potentially drive innovation in pediatric nutrition, an endeavor which surpasses research, clinical and academic thinking. The likelihood of translating innovative research concepts into practical applications depends on a large number of factors; Clinical studies, adherence to regulatory standards and environments of various countries, policy and politics on child health and nutrition, marketing issues, economic considerations as well as the state of food technology all determine whether and how a product can be brought to the market. Expectations and response of both consumers and health care professionals are likewise of very high importance. Due to its broad scope, this publication is of interest to everyone involved in one way or another in the development and launch of new products for pediatric nutrition.
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