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This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.
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When we began to organize the workshop "Calcium and Cellular Metabolism: Transport and Regulation" the goal we had in mind was to put together the knowledge of 2 several specialists on Ca + homeostasis, with various examples of cellular metabolisms 2 2 (such as protein synthesis), regulated by Ca + ions. Regarding the homeostasis of Ca + ions, we invited Ernesto Carafoli to write the first chapter as a general state-of-the-art introductory review. On the other hand, the other chapters are the contribution of different specialists on membrane calcium transport mechanisms, aiming to reunite at least in part the wide field of calcium homeostasis. We roughly try to group chapters that share simi...
Why would a university renowned for its school of medicine ever sell its teaching hospital? In his newest book, Dr. John A. Kastor presents an insider’s view of why university medical centers decide to sell teaching hospitals, why the decision might be a good one, and how such transitions are received by the faculty and administration. Kastor tells the story of two universities that, under financial duress for more than a decade, chose to sell their teaching hospitals. George Washington University sold to a national, for-profit corporation, Universal Health Services, Inc., and Georgetown University sold to a not-for-profit, local company, MedStar Health. Through interviews with key players involved in and affected by these decisions, Kastor examines the advantages and disadvantages of selling and describes the problems that can afflict medical schools that separate from their faculty practice plans. For the current leaders of medical schools facing similar financial challenges, Kastor analyzes how much it costs to teach clinical medicine and offers valuable advice on how to reduce expenses and increase surpluses.
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This volume concentrates on the analysis of the contributions of micro-scale elements on the structure and function of the cardiovascular system through pursuit of the characteristics of the basic elements: cells, organelles, genes, molecules, and ions, as well as the control mechanisms affecting the various interactions and functions. The general goals of this volume are to 1. foster interdisciplinary interaction among leading world scientists and clinical cardiologists in order to identify missing knowledge and catalyze new research ideas; 2. relate basic microscale, molecular, and subcellular phenomena to global clinically manifested cardiac performance; 3. apply conceptual modeling and quantitative analysis to better explore, describe, and understand cardiac physiology; 4. interpret available clinical data and design new revealing experiments; and 5. enhance international cooperation in the search for the secrets of life and their implications in cardiac pathophysiology.
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