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The Ethical and Legal Regulation of Human Tissue and Biobank Research in Europe
"Human tissue and biobank research is of increasing importance for understanding the causes of widespread diseases and developing effective therapies. However, while the success of biobank research depends on the availability of a large number of samples and the consolidation of collections across country borders is very desirable from the perspective of researchers, the legal and ethical requirements for the procurement, storage and use of human tissue samples are rather heterogeneous across different countries. Moreover, the lack of comprehensive supranational regulation on human tissue and biobanking can be seen as posing a serious threat to transnational biomedical research. Against this...
Ethics, Law and Governance of Biobanking
Biobank research and genomic information are changing the way we look at health and medicine. Genomics challenges our values and has always been controversial and difficult to regulate. In the future lies the promise of tailored medical treatments and pharmacogenomics but the borders between medical research and clinical practice are becoming blurred. We see sequencing platforms for research that can have diagnostic value for patients. Clinical applications and research have been kept separate, but the blurring lines challenges existing regulations and ethical frameworks. Then how do we regulate it? This book contains an overview of the existing regulatory landscape for biobank research in t...
The Porphyrin Handbook
The Porphyrin Handbook, Volume 12: The Iron and Cobalt Pigments: Biosynthesis, Structure, and Degradation provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book presents the biochemical and clinical aspects of genetically transmitted or drug-induced diseases associated with errors in heme metabolism. Organized into eight chapters, this volume begins with an overview of the comparison of regulatory principles in animal and plant tetrapyrrole biosynthesis. This text then examines the biology and medical implications of porphyrin systems. Other chapters consider the transformation of hemes into bile pigments, the organic synthesis of bilins, and the pathways of degradation of chlorophyll in senescent plants. This book discusses as well the biosynthesis of porphyrins, vitamin B12, and chlorophylls. The final chapter deals with genome sequencing projects that provide sources of genes encoding the enzymes needed for the synthesis of the intermediates. This book is a valuable resource for research scientists, engineers, and clinicians.
Handbook Of Porphyrin Science: With Applications To Chemistry, Physics, Materials Science, Engineering, Biology And Medicine (Volumes 41-44)
Porphyrins, phthalocyanines and their numerous analogs and derivatives are materials of tremendous importance in chemistry, materials science, physics, biology and medicine. They comprise the red color in blood (heme) and the green in leaves (chlorophyll); they are also excellent ligands that can coordinate with almost every metal in the Periodic Table. Grounded in natural systems, porphyrins are incredibly versatile and can be modified in many ways; each new modification yields derivatives demonstrating new chemistry, physics and biology, with a vast array of medicinal and technical applications.Because porphyrins are currently employed as platforms for study of theoretical principles and a...
The Barley Genome
This book presents an overview of the state-of-the-art in barley genome analysis, covering all aspects of sequencing the genome and translating this important information into new knowledge in basic and applied crop plant biology and new tools for research and crop improvement. Unlimited access to a high-quality reference sequence is removing one of the major constraints in basic and applied research. This book summarizes the advanced knowledge of the composition of the barley genome, its genes and the much larger non-coding part of the genome, and how this information facilitates studying the specific characteristics of barley. One of the oldest domesticated crops, barley is the small grain cereal species that is best adapted to the highest altitudes and latitudes, and it exhibits the greatest tolerance to most abiotic stresses. With comprehensive access to the genome sequence, barley’s importance as a genetic model in comparative studies on crop species like wheat, rye, oats and even rice is likely to increase.
