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In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development...
This interdisciplinary handbook provides extensive information about research in medieval studies and its most important results over the last decades. The handbook is a reference work which enables the readers to quickly and purposely gain insight into the important research discussions and to inform themselves about the current status of research in the field. The handbook consists of four parts. The first, large section offers articles on all of the main disciplines and discussions of the field. The second section presents articles on the key concepts of modern medieval studies and the debates therein. The third section is a lexicon of the most important text genres of the Middle Ages. The fourth section provides an international bio-bibliographical lexicon of the most prominent medievalists in all disciplines. A comprehensive bibliography rounds off the compendium. The result is a reference work which exhaustively documents the current status of research in medieval studies and brings the disciplines and experts of the field together.
George Spear (b.ca. 1613) immigrated about 1642 from England to Boston, Massachusetts, and settled at Braintree (now Quincy), Massachusetts in 1644. In his old age he moved to New Dartmouth (now Pemaquid), Maine, where his third wife had property; this would have been after 1678, when his second wife died. Descendants and relatives lived in New England, New York, New Jersey, Pennsylvania, Ohio, Minnesota, South Dakota, California and elsewhere.
Each chapter in this authoritative volume is written by a well-known physiologist who has contributed to our current understanding of renal function. Together the authors offer a unique, inside perspective on the historical record of the discipline, from its roots in the ancient world to the most recent findings of modern times. Among the many topics discussed are renal blood flow and the dynamics of glomerular filtration; the clearance concept in renal physiology; micropuncture and microperfusion; transport of electrolytes across renal tubules; and diuretics and renal drug development.