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Evolution of Genetic Mechanisms of Antibiotic Resistance
Since the first introduction of antibiotics into clinical practice, microbial drug resistance has emerged as a major obstacle in the treatment of infections. Recently, the combination of emergence of a complex variety of multidrug resistant strains and the dearth of newly discovered molecules to effectively target and eliminate these strains, has made antibiotic resistance one of the major public health problems of this century. Although different strategies can be adopted to contain the emergence and spread of antibiotic resistance, including (i) antimicrobial stewardship, (ii) infection control, and (iii) tighter control over the use of antibiotics in agriculture and breeding, a better und...
From Life Molecules to Global Health
Health care demands more and more cooperation and the convergence of all health related sciences, from Life Molecules to Global Health, as was most recently shown by the challenge of the COVID pandemic. This book brings together science contributions from NOVA’s researchers on biology and health, in the format of a broad life construct book.
Efflux-Mediated Antimicrobial Resistance in Bacteria
This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevan...
Antimicrobial Drug Discovery
Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Antibiotic Resistance Protocols
This book fully updates and builds upon its first edition. Beginning with chapters on epidemiology and population genetics, it continues with sections covering genomics and gene expressions, fitness mutation and physiology, and the detection of resistance.
FEMS Microbiology Letters
An international journal providing for the rapid publication of short reports on microbiological research.
