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Chronic Myeloid Leukemia: From Targeted Therapy to Treatment-Free Remission
Chronic Myeloid Leukemia (CML) is a hematopoietic stem cell disorder driven by the BCR-ABL1 oncogene which encodes for a non-receptor tyrosine kinase with constitutive deregulated kinase activity causing clonal expansion of leukemic stem cells. To date, the first line treatment for CML patients concerns the use of anti-ABL1 kinase drugs, known as Tyrosine Kinase Inhibitors (TKIs). A crucial aspect regarding CML and disease progression concerns the TKIs insensitivity properties of LSCs. In fact, although TKIs arrest the proliferation of committed Ph+ cells, they are ineffective to induce apoptosis of LSCs that preserving their self-renewal properties representing a reservoir of the disease. T...
Islamism, Arab Spring, and the Future of Democracy
This book provides an in-depth analysis of public opinion patterns among Muslims, particularly in the Arab world. On the basis of data from the World Values Survey, the Arab Barometer Project and the Arab Opinion Index, it compares the dynamics of Muslim opinion structures with global publics and arrives at social scientific predictions of value changes in the region. Using country factor scores from a variety of surveys, it also develops composite indices of support for democracy and a liberal society on a global level and in the Muslim world, and analyzes a multivariate model of opinion structures in the Arab world, based on over 40 variables from 12 countries in the Arab League and covering 67% of the total population of the Arab countries. While being optimistic about the general, long-term trend towards democracy and the resilience of Arab and Muslim civil society to Islamism, the book also highlights anti-Semitic trends in the region and discusses them in the larger context of xenophobia in traditional societies. In light of the current global confrontation with radical Islamism, this book provides vital material for policy planners, academics and think tanks alike.
Návraty
Konec druhé světové války je často vnímán jako ukončení násilí, počátek míru a návrat k normalitě. Avšak monografie Návraty. Poválečná rekonstrukce židovských komunit v zemích středovýchodní, jihovýchodní a východní Evropy ukazuje, že takový obraz je do značné míry zjednodušující. Kniha zkoumá nejen samotnou cestu přeživších holocaust zpět, ale především mnohost a různorodost toho, jak jejich fyzický a mentální návrat ovlivnil je samotné a jejich okolí. Kam se vlastně vracejí? Kdo na ně čeká? A jak společnost jejich návrat přijímá? Čtenář záhy pozná, že autobiografické příběhy přeživších, kteří prožili rasovou ...
Basarabia
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Dictionary of International Biography
A biographical record of contemporary achievement together with a key to the location of the original biographical notes.
Sustainable Fisheries and Aquaculture: Challenges and Prospects for the Blue Bioeconomy
The book presents expert assessments of modern opportunities for fisheries and aquaculture in terms of economic efficiency, the state of fishery reservoirs, and the state of ichthyocenoses. The purpose of this book is to provide interested parties (government bodies, representatives of business, science and civil society) with information about modern solutions in the field of aquatic biological resources management, the state of aquatic ecosystems and fish stocks, and modern and promising technologies in aquaculture and fisheries. The book contains an assessment of the state and recommendations for the restoration of natural aquatic ecosystems, an analysis of the state of fisheries and aquaculture in inland waters, taking into account regional characteristics, the development of a methodology for assessing freshwater fish stocks, information on advanced technologies in cage aquaculture in reservoirs and lakes and in circulation systems, data on opportunities for capacity building in small-scale fisheries, and the prospects for establishing a data and information management system for fisheries and aquaculture.
Geography and Ethnography
This fascinating volume brings together leading specialists, whohave analyzed the thoughts and records documenting the worldviewsof a wide range of pre-modern societies. Presents evidence from across the ages; from antiquity throughto the Age of Discovery Provides cross-cultural comparison of ancient societies aroundthe globe, from the Chinese to the Incas and Aztecs, from theGreeks and Romans to the peoples of ancient India Explores newly discovered medieval Islamic materials
