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Stories and photos that bring the spooky history of Western Michigan to life . . . Western Michigan is home to some of the state's most picturesque places—and also some of its most chilling tales. Ghost story researcher Amberrose Hammond exposes the mysterious and spirit-ridden world of many beloved Michigan destinations as she skillfully weaves narratives of a world unseen by most. From the lingering spirit forever working in the Grand Theatre and the band of melon-headed children prowling the Saugatuck Dunes State Park to the lights of the Lake Forest Cemetery staircase waiting to reveal one's place in the afterlife, these tales are sure to give pause to anyone daring enough to experience these hauntingly beautiful spots . . . after dark.
Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms. By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.
Accompanying CD-ROM (in v. 2) has image collections which can be saved in PowerPoint or HTML.
Each issue is packed with extensive news about important cancer related science, policy, politics and people. Plus, there are editorials and reviews by experts in the field, book reviews, and commentary on timely topics.
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The text is organized into two parts. Firstly, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial and Drosophila systems. Secondly, it covers current human genetics, clinical studies and the syndromes of abnormal sex differentiation.