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Immunological Role of the Maternal Microbiome in Pregnancy
Topic Editor Eytan R. Barnea is the Founder and Chief Scientific Officer of BioIncept, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Immunology at the feto-maternal interface
Reproductive biology is the mother of other areas in biology, as “Reproduction” had been the main strategy of simple and higher organisms to evolve. The utmost fitness in evolutionary tree is biological fitness, in being beneficial for successful reproduction. In this connection, reproductive sciences have been the focus of many research programs. Specifically, reproductive immunology has received the attention of researchers more than ever. This trend is largely due to the industrialization of societies, the increase in the age of marriage, and as a result, the decrease in fertility rates. On the other hand, despite significant advances in the field of artificial reproductive technologi...
Community Series in the Role of Complement in Health and Disease, volume II
The complement system is a crucial mediator of the innate immune response, interacting with other innate mechanisms and with factors of acquired immunity. It contributes significantly to cell homeostasis, tissue development and repair, reproduction, and cross-talk with other endogenous cascades. Each of the three major complement activation pathways (Classical, CP; Alternative, AP and Lectin, LP) employs specific recognition molecules and initiating serine proteases. All of them converge into a common pathway, leading to the formation of the biologically highly active anaphylatoxin C5a and the C5b-9 membrane attack complex (MAC). The latter forms transmembrane channels which either induce “sub-lytic” activation of the cell or result in target cell lysis. Although the complement system was discovered in 1888, nowadays this system is still under intense investigation with ongoing advances being made in various aspects including its clinical significance and its involvement in the regulation of the immune response.
The Collectin Protein Family and Its Multiple Biological Activities
The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging ...
Pearls and Pitfalls in Skin Ulcer Management
Thought as a primary reference on cutaneous ulcer management, written in a clear style by multidisciplinary experts and carefully edited and crafted, this volume covers of the complex topic of Wound Care, highlighting Pearls and Pitfalls in Skin Ulcer Management: from anatomy, epidemiology, pathogenesis and prevention, to diagnosis and selection of the best treatment options. This book also offers practical "how to do" advice and includes sections on cleaning and dressing, Negative-pressure wound therapy (NPWT), the latest on dermal substitutes, Platelet Rich Plasma (PRP) and Minimal Invasive Modality (MIMo) in burns. Specific parts illustrate how to assess a clinical wound measurement, and ...
Cancer Immunology
The rapid flow of studies in the field of cancer and immunology during the last decades has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it has been well-known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the crosstalk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. The Handbook of Cancer and Immunology offers a comprehensive and up-to-date review of cancer immunology and immunotherapy, emphasizing key findings and clinically relevant data. This reference work is an essential resource for researchers, students, academics, and clinicians committed to advancing knowledge, diagnostics, and treatments in this vital field.
