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A Practical Approach to Microarray Data Analysis
In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the identification of coexpressed genes, discovery of sample or gene groups with similar expression patterns, identi...
Quantified
Do biosensors biomedicalize? : sites of negotiation in DNA-based biosensing data practices / Mette Kragh-Furbo, Adrian Mackenzie, Maggie Mort, and Celia Roberts -- Data in the age of digital reproduction : reading the quantified self through Walter Benjamin / Jamie Sherman -- Biosensing : tracking persons / Sophie Day and Celia Lury -- The quantified self : reverse engineering / Gary Wolf -- Biosensing in context : health privacy in a connected world / Helen Nissenbaum and Heather Patterson -- Disruption and the political economy of self-tracking data / Mette Kragh-Furbo, Adrian Mackenzie, Maggie Mort, and Celia Roberts -- Deep data : notes on the n of 1 / Dana Greenfield -- Consumer health innovation opportunities and privacy challenges : a view from the trenches / Rajiv Mehta -- Open mHealth and the problem of data interoperability / Deborah Estrin and Anna de Paula Hanika, with Dawn Nafus -- Field notes in contamination studies / Marc Bãhlen -- Data, (bio)sensing and (other- )worldly stories from the cycle routes of london / Alex Taylor -- The data citizen, the quantified self and personal genomics / Judith Gregory and Geoffrey C. Bowker
The Quintessence of Basic and Clinical Research and Scientific Publishing
The book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clini...
Postgenomics
Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences. Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens
Genome Research
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AI Magazine
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