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Who made modern Britain? This book, drawn from the award-winning Oxford Dictionary of National Biography, tells the story of our recent past through the lives of those who shaped national life. Following on from the Oxford DNB's first supplement volume-noteworthy people who died between 2001 and 2004-this new volume offers biographies of more than 850 men and women who left their mark on twentieth and twenty-first century Britain, and who died in the years 2005 to 2008. Here are the people responsible for major developments in national life: from politics, the arts, business, technology, and law to military service, sport, education, science, and medicine. Many are closely connected to speci...
First multi-year cumulation covers six years: 1965-70.
First multi-year cumulation covers six years: 1965-70.
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. - Outlines the chemical features of PNH - Explains the mechanism of hemolysis - Includes work on the biochemistry of glycophosphoinositol anchors - Contains descriptions of the chemistry and biophysics of GPI-anchored proteins
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