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TH17 Cells in Health and Disease
“About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, pres...
Bone Marrow Purging and Processing
This volume assesses research findings as well as the clinical aspects now in use for selectively separating subpopulations of cells from bone marrow. It examines a full range of purging processes including transplantation programs, cryopreservation, cell isolation and cell growth, specificity testing and quality control, as well as the development of alternative sources of stem cells, including peripheral blood and cadaveric marrow. It also presents the conditions necessary to optimize graft toxicity and bone marrow transportation and addresses newer techniques of gene probing/processing as well as mechanisms of genetic alteration including electroporation.
Philosophical Transactions
Each issue of Transactions B is devoted to a specific area of the biological sciences, including clinical science. All papers are peer reviewed and edited to the highest standards. Published on the 29th of each month, Transactions B is essential reading for all biologists.
