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Principles of Molecular Medicine
Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.
Malady of the Mind
"This brilliant portrait of schizophrenia--the most malignant and least understood mental illness--by renowned psychiatrist Jeffrey Lieberman, Chair of Columbia's legendary Psychiatry department, interweaves cultural and scientific history with dramatic patient portraits and clinical experiences to impart a revolutionary message of hope: that for the first time in human history, schizophrenia can not just be effectively treated, but even prevented. Of the many myths and misconceptions that have historically obscured our understanding of schizophrenia, the most pernicious is that there is no effective treatment or cure. The reality couldn't be more different: the truth is that today's treatme...
Inheritance of Kidney and Urinary Tract Diseases
Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disorders into the forefront of pediatrics. One is a great reduction in childhood mortality due to infections and nutritional deficiency states, and the other is the rapid progress made in the identification of genetic defects. Amniocentesis, chorionic villus sampling, and recombinant DNA technology have already had a tremendous impact on the practice of medicine. This is why the first two chapters of thi...
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Molecular and Cytogenetic Studies of Non-disjunction
Trisomy 21 is the most common genetic disorder in humans. The present volume reviews the results of molecular and cytogenetic techniques performed on four organisms--humans, mice, "Drosophila," and yeast. Examined are the association between meiotic recombination and chromosome disjunction, increasing maternal age and non-disjunction in humans, and genetic factors that may contribute to a predisposition to non-disjunction. Molecular analyses involving different human chromosomes, the importance of tissue-specific trisonomy, and the significance of specific etiological agents to non-disjunction are also considered.
