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Polyextremophiles
Many Microorganisms and some macro-organisms can live under extreme conditions. For example, high and low temperature, acidic and alkaline conditions, high salt areas, high pressure, toxic compounds, high level of ionizing radiation, anoxia and absence of light, etc. Many organisms inhabit environments characterized by more than one form of stress (Polyextremophiles). Among them are those who live in hypersaline and alkaline, hot and acidic, cold/hot and high hydrostatic pressure, etc. Polyextremophiles found in desert regions have to copy with intense UV irradiation and desiccation, high as well as low temperatures, and low availability of water and nutrients. This book provides novel results of application to polyextremophiles research ranging from nanotechnology to synthetic biology to the origin of life and beyond.
Targeted Radiopharmaceuticals and Imaging
Targeted radiopharmaceutical therapy (RPT) is emerging as an innovative approach for treating a wide range of cancers. Almost all radionuclides used in RPT emit photons that can be imaged, enabling non-invasive visualization of the therapeutic agent's biodistribution. The remarkable potential of radiopharmaceutical therapy is now being recognized with recent FDA approval of several RPT drugs and a significant number of drug candidates in clinical development. This book offers a comprehensive perspective on the different technologies and addresses the critical challenges in developing and commercializing radiopharmaceuticals. It covers various topics, from clinical applications to specific ra...
Tumor Response Monitoring and Treatment Planning
Medical imaging progressed to a standard undreamt of not very many years ago. The advances are due to continuous development of radiological techniques and the introduction of magnetic resonance imaging. With the improved and new methods three-dimensional target volumes for radiation therapy can be defined with hitherto unknown precision. This leads to an improvement in irradiation techniques and, as a consequence, to a higher likelihood of tumor control and a lower risk of normal tissue complications. Besides the improvement in irradiation techniques the new imaging methods may enable great strides in tumor response monitoring, not only in the detection of morphological alterations but also by showing physiological changes in the tumor during and after treatment by means of MRI and PET. This not only leads to better prognostic information but may also allow early evaluation of the response to treatment. It may then be possible to individualize the radiation dose but also the alternative-treatment for non-responders. This is certainly a future direction for radiation oncology.
MRI of the Prostate
Learn the fundamental principles and clinical applications of the diagnostic and risk assessment imaging test of choice for prostate cancer: prostate MRI Although prostate cancer is the second leading cause of cancer death in men in the USA, it can be treated successfully if detected early. Disease management has gradually changed to a paradigm that relies on close monitoring through active surveillance in select patients, as well as ongoing refinements in treatment interventions, including minimally invasive procedures. This has resulted in a critical need for a more exacting methodology for performing targeted biopsies, assessing risk levels, and devising treatment strategies. Prostate MRI...
The Survey
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Radiotherapy in Prostate Cancer
Today, the arsenal of “high-precision” or “targeted” radiotherapy includes a variety of techniques and approaches that, like the pieces of a puzzle, need to be put together to provide the prostate cancer patient with high-level optimized radiation treatment. This book examines in detail the role of these innovative radiation techniques in the management of prostate cancer. In addition, a variety of current controversies regarding treatment are carefully explored, including whether prophylactic treatment of the pelvic lymphatics is essential, the magnitude of the effect of dose escalation, whether a benefit accrues from hypofractionation, and what evidence exists for the superiority of protons or heavy ions. Radiotherapy in Prostate Cancer: Innovative Techniques and Current Controversies is intended for both radiation oncologists and urologists with an interest in the up-to-date capabilities of modern radiation oncology for the treatment of prostate cancer.
Technical Basis of Radiation Therapy
This well-received book, now in its fifth edition, is unique in providing a detailed examination of the technological basis of radiation therapy. Another unique feature is that the chapters are jointly written by North American and European authors. This considerably broadens the book’s contents and increases its applicability in daily practice throughout the world. The book is divided into two sections. The first section covers basic concepts in treatment planning and explains the various approaches to radiation therapy, such as intensity-modulated radiation therapy, tomotherapy, stereotactic radiotherapy, and high and low dose rate brachytherapy. The second discusses in depth the practical clinical applications of the different radiation therapy techniques in a wide range of cancer sites. All chapters have been written by leaders in the field. This book will serve to instruct and acquaint teachers, students, and practitioners with the basic technological factors and approaches in radiation therapy.
