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Genomic Uracil: Evolution, Biology, Immunology And Disease
This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, repli...
DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells
This volume contains edited contributions from the speakers at the NATO Advanced Research Workshop on "DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con tributions to the DNA repair field include the cO-discovery of the excision repair pathway, the elucidation of post-repli cation repair in E. coli, the isolation of the lexA and recC mutants, and his extensive work on the enzymology of RecA. A plethora of recent developments in DNA repair mechan isms and related processes in mammalian cells have advanced our understanding of this field in a number of different areas and have given new emphasis to the ways these systems both resemble DNA repair processes in other groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.
Advances in DNA Damage and Repair
Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is rega...
Miracles in Biochemistry
It will be a source of inspiration to the science students, teachers and early career Biochemist.It explore the life and works of famous Biochemist, whose groundbreaking achievements won the Nobel Prize and shaped the field of Biochemistry.
Ancient DNA
The untold story of the rise of the new scientific field of ancient DNA research, and how Jurassic Park and popular media influenced its development Ancient DNA research—the recovery of genetic material from long-dead organisms—is a discipline that developed from science fiction into a reality between the 1980s and today. Drawing on scientific, historical, and archival material, as well as original interviews with more than fifty researchers worldwide, Elizabeth Jones explores the field’s formation and explains its relationship with the media by examining its close connection to de-extinction, the science and technology of resurrecting extinct species. She reveals how the search for DNA from fossils flourished under the influence of intense press and public interest, particularly as this new line of research coincided with the book and movie Jurassic Park. Ancient DNA is the first account to trace the historical and sociological interplay between science and celebrity in the rise of this new research field. In the process, Jones argues that ancient DNA research is more than a public-facing science: it is a celebrity science.
Ask the Parrot
Sometimes mystery master Donald E. Westlake is the author of uproarious crime capers. Sometimes he has a mean streak-and its name is Parker. From his noir classic The Man with the Getaway Face to his recent novel Nobody Runs Forever, whenever Westlake writes as Stark, he lets Parker run loose-a ruthless criminal in a world of vulnerable "straights." On a sunny October afternoon a man is running up a hill. He's not dressed for running. Below him are barking police dogs and waiting up ahead is a stranger-with a rifle, a life full of regrets, and a parrot at home who will mutely witness just how much trouble the runner, Parker, can bring into an ordinary life. The rabbit hunter is Tom Lindahl, ...
DNA Repair Processes
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