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Regenerative Medicine and Plastic Surgery
This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspec...
Muscle Atrophy
The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thi...
Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
Chronic Muscle Spasm and Pain
Chronic Muscle Spasm and Pain: Discoveries in the Etiology, Identification and Treatment of Chronic Muscle Spasm and Resultant Chronic Pain By: Roger H. Coletti, MD, FACC, FASNC, FSCAI As an interventional cardiologist Dr. Roger H. Coletti recognized the true nature of atrophic myofibers described in biopsies harvested from horses suffering spams syndrome: that they were not "denervated muscle fibers", but "hibernating skeletal muscle fibers", which can become triggers for chronic pain. These new concepts explain why treating chronic muscle spasm in skeletal muscles with BOTOX or other pharmacological inhibitors of neuromuscular synaptic function which includes phenoxybenzamine, can relieve ...
Muscle Damage
The treatment and prevention of muscle damage makes many demands on the time and attention of practioners of sports, occupational and clinical medicine. Despite this, surprisingly little is known about the mechanisms responsible for such damage. This book provides a comprehensive statement of what is currently known about muscle damage and what is yet to be learnt, in terms of both the underlying science and strategies for clinical management. Each chapter gives an account of up-to-date knowledge on a relevant topic. Based upon an issue of the Journal of Basic and Applied Myology, the text has been rewritten, restructured and expanded, so that the content is completely up-to-date.
