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Cell-Penetrating Peptides
One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a
Muscarinic Receptor Subtypes in Smooth Muscle
This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.
Neurotransmitter Receptors in Actions of Antipsychotic Medications
Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have few
Placental Pharmacology
Placenta plays a very significant role in the development of secretory and regulatory functions for the maintenance of pregnancy and in the nutrition of the embryo. It shares many functions of the heart, lung, liver, endocrines, and other organs. In Placental Pharmacology, fourteen expert authors discuss how placenta and its component parts can be used effectively in drug development research and in the study of transfer mechanisms across membranes. This reference begins by describing the use of modern biophysical methods to study placental function and prospects for their application in pharmacological research. The next three chapters deal with placental hemodynamics, use of placental tiss...
Airway Wall Remodelling in Asthma
Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsi...
Therapeutic Modulation of Cytokines
Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular ...
PARP as a Therapeutic Target
Recent research in cell death mechanisms has rekindled interest in PARP's (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors' dual actions of preventing cell death and abating inflammati
Antibody Therapeutics
Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.
Pharmacology in Exercise and Sports
This is the first book to describe the pharmacological interaction of drugs and exercise with organ systems at molecular and cellular levels. It explains the effect of exercise on pharmacokinetics and pharmacodynamics of drugs, and the activation or induction of antioxidant enzymes which may take place via the adenosine receptor or may occur due to gene expression.
Taxol
This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.
