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The Neuroscience of Pain, Anesthetics, and Analgesics
The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia. The book works to clar...
Resolution Pharmacology - Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies
In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this ...
Nrf2 and its Modulation in Inflammation
Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation, respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics
Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the cause of the pain, and the administration of analgesia or anesthesia. The etiology of pain is complex and multi-factorial, which is made more complex with the use of analgesics and local or general anesthetics. This volume works to clarify all of the subjects pertinent to anesthesia and the brain, from their variety, modes of action, and adverse effects. - Provides a broad range of topics related to the neuroscience of analgesics and anesthetics - Contains chapter abstracts, key facts, a dictionary of terms, and summary points to aid in understanding - Discusses anesthesia types, mechanisms of action and affiliated effects - Helps readers navigate key areas for research and further clinical recommendations
Frontiers in CNS Drug Discovery
Frontiers in CNS Drug Discovery is a book series devoted to publishing reviews which highlight the latest advances in drug design and discovery for disorders of the central nervous system (CNS). Eminent scientists write contributions on all areas of CNS drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series is essential reading for all pharmaceutical scientists involved in CNS drug design and discovery who wish to keep abreast of rapid and important developments in the field. The third volume of this series brings reviews on brain tumor treatment, neurodegeneration, hyperalgesia, cholinesterase inhibition and much more.
Interleukin-33 Biology in Tissue Development, Homeostasis and Disease
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Naturally
Unlock the power of herbalism to transform your health and life While modern medicine can only take us so far, herbalism—the science and art of plants as medicine—stands the test of time. In Naturally, clinical herbalist Rachelle Robinett offers a beginner-friendly guide to herbalism, revealing everyday remedies and rituals for health and happiness. Herbs allow you to take control of every aspect of your health in a way that’s natural, sustainable, and completely customizable. Better yet, you don’t need fancy equipment or an extensive pantry to start—just a desire to feel better, naturally. Weaving practical advice with deep explorations of herbalism’s potential to shift our rela...
Naturally
When it comes to our health and well-being, modern treatments can take us only so far. What we're missing is a holistic, individualised and natural approach that addresses the roots of our discomfort with life-changing results. In other words, we need herbalism. Introducing herbalism as a vital layer of our well-being, clinical herbalist Rachelle Robinett reveals the natural remedies and rituals that can boost our health and happiness. Did you know that cloves and turmeric have analgesic properties that relieve pain? That if you struggle with anxiety, nervines such as lemon balm help quiet spiralling thoughts? That for a boost of motivation, nootropics like lavender support healthy dopamine levels, while adding bitters to your diet can improve digestion? Walking readers through the key herbal categories, their functions and how to best use them, Naturally shows how herbalism can be applied to all aspects of your life and offers simple recipes and formulas for herbal remedies that will empower you to reclaim your health.
Immune and Glial Regulation of Pain
"Review of immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states. Discussion of novel immune and glial targets for clinical pain control that may yield new analgesic drugs"--Provided by publisher.
