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Bone Metastases
The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
Life System Modeling and Simulation
This book is part of a two-volume work that constitutes the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2007, held in Shanghai, China, September 2007. Coverage includes modeling and simulation of societies and collective behavior, computational methods and intelligence in biomechanical systems, tissue engineering and clinical bioengineering, computational intelligence in bioinformatics and biometrics, and brain stimulation.
Novel Molecular Oncotargets and Nano-Oncotherapeutics
This book describes the latest findings related to tumor molecular microenvironment and its involvement in cancer progression. It includes authoritative articles on recent progress in the field based on the current results of apoptosis, autophagy, and tumor signaling highlight new cancer targets for therapeutic manipulation as a strategy of cancer control. It explores the advancements of molecular mechanisms in oncology to identify new therapeutic, prognostic, and diagnostic targets in the molecular events of neoplasia. Recent data on nanoformulations in the book for the therapeutic management of various types of cancer indicate a revolutionary change in cancer therapy in the near future. The primary audience of this book is students and faculties from academic institutions, the researchers, scientists, clinicians, and scientists belong to the research and development wing in industries, as the book provides the latest data and findings in the described areas as a valuable source of incredible information in the field in an organized manner.
Central Nervous System Metastasis, the Biological Basis and Clinical Considerations
This volume will cover what is known regarding the biology and treatment of CNS metastasis, including novel chapters such as the future of targeted therapies. It will begin with an overview of the natural history and risk factors for CNS metastases that will broadly cover all cancer histologies. This will be followed by 3 chapters that will cover the biology. These include: molecular biology, discussing what is known about specific genes/proteins involved in the process and model systems to study brain metastasis; the brain microenvironment, focusing on how it is different from the microenvironment of other organs of the body; and the blood-brain barrier, which includes a discussion of permeability with respect to brain metastases. A chapter on experimental imaging will cover both the biology of brain metastasis from an imaging perspective and use of imaging techniques to study brain metastases. The clinical chapters will discuss treatment options with separate chapters on surgery, chemotherapy and radiation. In addition, leptomeningeal metastasis will be given its own chapter. Finally, quality of life issues will be the concluding chapter.
Bone Metastasis and Molecular Mechanisms
Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer. Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.
Micrometastasis
Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.
Cancer Metastasis — Related Genes
Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summari...
