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Strictly speaking, the term regulatory peptides may include any peptide which has a regulatory function in any organism. In recent years, how ever, the term has come to mean those originally classified as brain-gut peptides. The peptides initially defined as those belonging to the brain gut axis had a dual location in neurones of the brain and endocrine cells of the gut. We now include a number of neuropeptides found in the autonomic nervous system of the gut, the cardiovascular system and other systems. To many scientists comparative physiology means comparison of the mechanisms of certain functions in the rat, the guinea-pig, the cat and maybe some other mammal. If the philosophy is that m...
This book provides a state-of-the-art account by academic respiratory physicians and senior pharmaceutical industry personnel on the development of new drugs for asthma, allergy and COPD. It contains 80 chapters of highly condensed information, presented in an attractive, reader-friendly format with much use of tables, figures and diagrams. In addition to summarizing the diverse range of current approaches, this handbook also looks into the future, considering many topics that are promising, but have only emerged in the last few years. Developments within established drug categories such as beta-2-agonists, steroids and leukotriene antagonists are also reviewed. Never before has a single book brought together so many pharmaceutical drug developers sharing their experience on such a wide range of respiratory topics!
This book describes the crucial scientific interface between central neurotransmitter regulation and interacting hormonal pathways. It provides a review of the previously published literature on neuroendocrine mechanisms and brings the reader up-to-date with the latest developments in the field. Chapters cover the following areas: -- cellular interactions of neurotransmitters to induce specific release of a peptide hormone -- the role of opioids in the regulation of reproductive hormones and the possible implication of endorphins and enkephalins in developmental endocrinology -- immunohistochemical localization of vasoactive intestinal polypeptide as a tool to distinguish the possible role of the peripheral nervous system from that of central nervous control in stress and pathological situations -- developmental endocrinology and neurohormonal control of the ovarian cycle.
With contributions from experts in the field, this book provides a comprehensive overview of the oxidative folding of cysteine-rich peptides.
This volume contains papers presented at the Third International Symposium which focused on thoracic organ transplantation. Areas covered include: cardiac transplantation; basic research; mechanical circulatory support; heart transplantation in infancy and childhood; and heart-lung transplantation.