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The ancestry of General James Wilkinson (1757-1825) was born in Calvert County, Maryland to Joseph Wilkinson II (1731-1764) and Betty Heighe (1733-1802). The Wilkinson family first arrived from England in the early 1700s with Captain Joseph Wilkinson. Other ancestors arrived in the late 1600 and became influential in the colony of Maryland. In 1778 James married Ann Biddle and they were the parents of three children. After her death in 1807 he married Celestine Laveau Trudeau and they were the parents of four children. Descendants live in Louisiana and other parts of the United States.
William Ames was baptized 6 October 1605 in Bruton, Somerset, England. His parents were John Ames and Christian Browne. He emigrated in about 1635. He married Hannah in about 1639. They had six children. He died in Braintree, Massachusetts in 1653. Descendants and relatives lived mainly in Massachusetts, Connecticut, Rhode Island, Maine, New York, Pennsylvania, Ohio, Illinois, Michigan, Wisconsin, Minnesota and Missouri.