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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily ...
New Frontiers of Molecular Epidemiology of Infectious Diseases
Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmiss...
Decision Support Systems and Education
Medical informatics has revolutionized healthcare in recent years, and one of the major challenges now faced by health professionals everywhere is the further improvement of healthcare by making more effective use of the data from biomedical informatics, not least for education and decision support. This book presents the 52 full papers (accepted from 95 initial submissions) delivered at the Special Topic Conference of the European Federation for Medical Informatics (EFMI STC 2018), held in Zagreb, Croatia, on 15 and 16 October 2018. The EFMI STC is one of Europe`s leading conferences for the sharing of current professional and scientific knowledge in health informatics processes, and the topics covered here have been broadly divided into two sections; decision support and education. Offering an overview of current medical informatics research, this book will undoubtedly prove invaluable for the professional development of healthcare practitioners, as well as contributing to knowledge sustainability within the field of medical informatics.
Diseases at the Wildlife - Livestock Interface
Shared diseases among wildlife, livestock and humans, often transboundary, are relevant to public health and global economy, as being highlighted currently relative to the global COVID19 pandemic. Diseases at these interfaces also impact the conservation of biodiversity and must be considered when managing wildlife. While wildlife and domestic livestock have coexisted in dynamic systems for thousands of years, spillover disease risks are higher today than in the past due to global patterns of increasing close contact and interactions among wildlife, livestock and humans in the context of complex, diverse and numerous circumstances. Multidisciplinary studies of animal interfaces, especially t...
Transfrontier Conservation Areas
The introduction of transfrontier conservation areas (TFCAs) in southern Africa was based on an enchanting promise: simultaneously contributing to global biodiversity conservation initiatives, regional peace and integration, and the sustainable socio-economic development of rural communities. Cross-border collaboration and eco-tourism became seen as the vehicles of this promise, which would enhance regional peace and stability along the way. However, as these highly political projects take shape, conservation and development policymaking progressively shifts from the national to regional and global arenas, and the peoples most affected by TFCA formation tend to disappear from view. This book...
The Scrolls of Onteora - The Cremona Document (Collectors Edition - Full Color)
From the ancient city of Jerusalem to the mountains of New York, the Scrolls of Onteora, known as the Cremona Document, tell the story of the Knights Templars who found artifacts and documents, revealing how the scrolls were transported to the Americas centuries before they were settled by Europeans. Learn the meaning of these artifacts found beneath the walls of Jerusalem and follow Ralph de Sudeley and his companions as they endeavor to recover these lost scrolls. Examine the pictures and documents that Don Ruh has accumulated about them over the last 30 years and weigh the evidence yourself. Front cover: A modern view of ancient Jerusalem Rear cover photo: The mountains of New York
